Evidence map›Paper›PMID 42564605›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Role of sex and ethnicity in the relationships among physical activity, cognition, and AD biomarkers in the HABS-HD cohort.

Jansie H Nel, Joel S Burma, Tamara S Bodnar, Meghan McDonough, Gregory Knell, Melissa Petersen, Sid E O'Bryant, Cindy K Barha, Health and Aging Brain Study (HABS‐HD) Study Team

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jansie H NelBarha Brain Health Laboratory, Faculty of Kinesiology University of Calgary Calgary Alberta Canada.
Joel S BurmaBarha Brain Health Laboratory, Faculty of Kinesiology University of Calgary Calgary Alberta Canada.ORCID https://orcid.org/0000-0001-9756-5793
Tamara S BodnarDepartment of Biological Sciences University of Calgary Calgary Alberta Canada.
Meghan McDonoughFaculty of Kinesiology University of Calgary Calgary Alberta Canada.
Gregory KnellDepartment of Population & Community Health, College of Public Health University of North Texas Health Science Center Fort Worth Texas USA.
Melissa PetersenDepartment of Pharmacology & Neuroscience University of North Texas Health Science Center Fort Worth Texas USA.
Sid E O'BryantInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Cindy K BarhaBarha Brain Health Laboratory, Faculty of Kinesiology University of Calgary Calgary Alberta Canada.
Health and Aging Brain Study (HABS‐HD) Study Team

Funding

The Health & Aging Brain Study - Health Disparities (HABS-HD)U19AG078109 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI LEIGH A JOHNSON · 2022 to 2026
$181.1M
Health and Aging Brain among Latino Elders (HABLE-AT(N)) StudyR01AG058533 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JOHNSON, LEIGH A, O'BRYANT, SID E · 2020 to 2025
$45.4M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2022
$14.1M
Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican AmericansR01AG054073 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E, TOGA, ARTHUR W · 2017 to 2021
$12.6M
Epigenetic Risk Factors for AD Age at Onset and Health Disparities: HABLE Epigenetics StudyR01AG070862 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI BARBER, ROBERT CLINTON · 2021 to 2025
$3.4M
NIA NIH HHS R01 AG054073NIA NIH HHS R01 AG058533NIA NIH HHS R01 AG070862NIA NIH HHS U19 AG078109NIBIB NIH HHS P41 EB015922
6 · The paper itself

Abstract

introductionDementia prevalence is rising with population aging, disproportionately affecting females and ethnically diverse groups. Physical activity (PA) may mitigate age-related cognitive and brain decline; sex- and ethnicity-specific associations remain poorly understood.

methodsData from the Health and Aging Brain Study-Health Disparities were analyzed from 3585 participants (63% female). PA was categorized using the Rapid Assessment of Physical Activity (RAPA) questionnaire as no/little (< 4) or moderate/high (≥ 4). Outcomes included cognitive composites, plasma biomarkers, and magnetic resonance imaging-derived hippocampal subregions and dorsolateral prefrontal cortex volumes.

resultsHigher PA was associated with higher global cognition and executive functions in all females and in Hispanic males (

conclusionsFindings support PA as a modifiable factor associated with healthy brain aging, emphasizing the importance of incorporating sex and ethnicity into future research.

Indexed as

cognitive agingethnic disparitiesneurodegeneration biomarkersphysical activitysex differences

Identifiers

PMID42564605
PMCPMC13445254

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.