SynthesisFrontiers in aging neuroscience2026
Association between BDNF and postoperative cognitive dysfunction across surgical stages: a systematic review and meta-analysis.
Synthesis in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Postoperative cognitive dysfunction (POCD) is a frequent complication after surgery, particularly among older adults, and its underlying mechanisms remain incompletely understood. Brain-derived neurotrophic factor (BDNF) is a key regulator of neuronal survival and synaptic plasticity, and has been implicated in POCD but published findings are inconsistent. We therefore performed a systematic review and meta-analysis to evaluate the association between perioperative BDNF levels and POCD across surgical time points. Following PRISMA guidelines, we searched PubMed, EMBASE, Web of Science, and Scopus were searched for observational studies that reported perioperative BDNF levels in patients with and without POCD. Two reviewers independently extraction data and assessed study quality using the Newcastle-Ottawa Scale. Statistical analyses were conducted in RevMan 5.3, with mean differences (MD) with 95% confidence intervals (CI) were calculated for absolute BDNF levels and perioperative changes (ΔBDNF) at preoperative, intraoperative, and postoperative stages. Six studies including 135 patients with POCD and 247 without POCD met the inclusion criteria. The fixed-effects meta-analysis showed lower intraoperative BDNF levels in the POCD group (MD = -5.62, 95% CI[-8.95, -2.29],
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