Evidence map›Paper›PMID 42564567›Full record

ArticleNAM journal2026

Preparing for CHANGE: How systems thinking supports an effective transition from animal studies to NAMs.

Gro H Mathisen, Paul Whaley, Birgit Kopainsky, Heather M Ames, Sebastian Hoffmann, Trine Husøy, Lowenna B Jones, Camilla Svendsen, Gunn E Vist, Denise Bloch and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NAM journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Gro H MathisenNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.
Paul WhaleyNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.
Birgit KopainskyNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.
Heather M AmesNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.
Sebastian HoffmannEvidence-based toxicology collaboration (EBTC), Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA.
Trine HusøyNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.
Lowenna B JonesNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.
Camilla SvendsenNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.
Gunn E VistNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.
Denise BlochDepartment of Pesticides Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Aleksandra CavoskiBirmingham Law School, University of Birmingham, UK.
Weihsueh A ChiuDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Holly G DaviesWashington State Department of Health, Tumwater, WA, USA.
Arianna GiustiCosmetics Europe Avenue Herrmann-Debroux 40, 1160, Auderghem, Belgium.
Thomas HartungCenter for Alternatives to Animal Testing (CAAT), Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA.
Helena T HogbergDivision of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Seok KwonDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Olivia J OsborneChemical Risk Assessment Team, Science Evidence and Research Division, Food Standards Agency, Westminster, London, United Kingdom.
Andrew A RooneyDivision of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Christophe RousselleANSES/DAEI-French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre et Marie Curie, Maisons-Alfort Cedex, 94701, France.
Jennifer B SassNatural Resources Defense Council, Washington, DC, USA.
Ulla SimanainenEuropean Chemicals Agency, Helsinki, Finland.
Kristina A ThayerOffice of Environmental Health Hazard Assessment, 1001 I street, Sacramento, California, 95814, USA.
Daniele WikoffToxStrategies, Asheville, NC, USA.
Angela BearthNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

None.

Indexed as

Drivers of system behaviourEffective use of NAMsSystem dynamicsSystem-level interventionsSystems modellingSystems thinking

Identifiers

PMID42564567
PMCPMC13445476

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.