ArticleFrontiers in medicine2026
Major discrepancy between clinical and autopsy diagnosis: a descriptive single-center analysis and its implications for the South African public health system.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: A global decline in the number of clinical post-mortems sought and conducted indicates a diminishing necessity for post-mortem exams. Notwithstanding advancements in medical technology, autopsies continue to serve as a pertinent method for ascertaining the cause of death. Objectives: This study aimed to identify prevalent major misdiagnoses in clinical settings through autopsy and to investigate potential contributing factors. Methods: A retrospective cross-sectional study was conducted, including 51 autopsies retrieved from the NHLS Laboratory Information System (LIS) and classified as either Class I or Class II discrepancies according to the Goldman criteria. Stata-18 was used to analyse descriptive data and examine the associations between clinicopathological factors and the major discrepancy classes. Results: Of the 51 autopsies included in the study, 68.63% ( Conclusions: Autopsies remain a pertinent clinical audit tool despite advances in medical technology. The hospital should provide funds for autopsies and encourage doctors to utilize them as a clinical audit instrument to enhance patient management.
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