Evidence map›Paper›PMID 42564426›Full record

ArticleiScience2026

FAP-derived CCL2 is required for adequate monocyte/macrophage infiltration to support acute skeletal muscle injury repair.

Xingyu Wang, Yinhang Wang, Ruoxi Yuan, Gregory R Smith, Frederique Ruf-Zamojski, Sachiko T Homma, Stuart C Sealfon, Lan Zhou

Abstract read
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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xingyu WangDepartment of Neurology, Hospital for Special Surgery, 535 East 70 Street, New York, NY 10021, USA.
Yinhang WangDepartment of Neurology, Hospital for Special Surgery, 535 East 70 Street, New York, NY 10021, USA.
Ruoxi YuanGenomics Center Bioinformatics Core, Hospital for Special Surgery, 515 East 71 Street, New York, NY 10021, USA.
Gregory R SmithDepartment of Neurology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, NY 10029, USA.
Frederique Ruf-ZamojskiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, NY 10029, USA.
Sachiko T HommaDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.
Stuart C SealfonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, NY 10029, USA.
Lan ZhouDepartment of Neurology, Hospital for Special Surgery, 535 East 70 Street, New York, NY 10021, USA.

Funding

Origins and Functions of Intramuscular Macrophages in Duchenne Muscular DystrophyR01AR074428 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI ZHOU, LAN · 2019 to 2023
$1.8M
NIAMS NIH HHS R01 AR074428
6 · The paper itself

Abstract

Repair of acutely injured skeletal muscle relies on an adequate inflammatory response predominated by monocyte/macrophage infiltration. The process requires injured muscles to produce C-C chemokine ligand 2 (CCL2). The present study identified fibro/adipogenic progenitors (FAPs) as the primary source of CCL2 in acutely injured muscle, where the pro-inflammatory subcluster of FAPs expanded rapidly and expressed the highest level of CCL2. FAP-specific deletion of

Indexed as

acute muscle injuryCCL2FAPsmonocytes and macrophagesmuscle regeneration

Identifiers

PMID42564426
PMCPMC13444261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.