ArticleKorean journal of neurotrauma2026
Clinically Relevant Blood Pressure Elevation During Apnea Testing for Brain Death Determination: Association With Circulating Catecholamines.
Article in Korean journal of neurotrauma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To characterize hemodynamic changes during apnea testing for brain death determination and evaluate their clinical relevance while exploring associations with circulating catecholamines. Methods: We retrospectively analyzed 27 patients who underwent apnea testing between January 2020 and March 2024. Each patient underwent two apnea tests, during which heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were measured at baseline and within 1-7 minutes after testing. Peak post-test values were compared with baseline values. Plasma catecholamines were measured before and after the first test in a subset of 13 patients. Results: Both apnea tests were associated with significant increases in cardiovascular parameters. Median SBP increased from 123.5 mmHg (interquartile range [IQR], 109.2 to 142.0) to 147.5 mmHg (IQR, 128.0 to 178.8; Conclusion: Apnea testing consistently induced clinically relevant increases in blood pressure and HR without corresponding elevations in circulating catecholamines, suggesting additional mechanisms may contribute to these hemodynamic responses during apnea testing.
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