Evidence map›Paper›PMID 42564368›Full record

ArticleNeurotrauma reports

Pediatric Repetitive Mild Traumatic Brain Injury Elicits T Cell-Mediated Neuroinflammation.

Kirill Shumilov, Lindsay Arellano, Yongyun Shin, Grace Dominguez, Rajiv Swarup, William Bernhardt, John Greer, James P McAllister, Maria Garcia-Bonilla, Kimberle Jacobs and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kirill ShumilovDepartment of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA.
Lindsay ArellanoDepartment of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA.
Yongyun ShinDepartment of Biostatistics, Virginia Commonwealth University, Richmond, Virginia, USA.
Grace DominguezDepartment of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA.
Rajiv SwarupDepartment of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA.
William BernhardtDepartment of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA.
John GreerDepartment of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA.
James P McAllisterDepartment of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA.
Maria Garcia-BonillaDepartment of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA.
Kimberle JacobsDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia, USA.
David D LimbrickDepartment of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA.

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Renato Martins · 1985 to 2026
$51.0M
NCI NIH HHS P30 CA016059
6 · The paper itself

Abstract

Pediatric repetitive mild traumatic brain injury (rmTBI) is a major public health concern with links to chronic cognitive dysfunction. Neuroinflammation represents a significant maladaptive outcome after rmTBI. Persistent innate and adaptive immune cell responses can lead to neurodegeneration and deficits in brain development. Therefore, a deeper understanding of the early dynamics of peripheral immune cell infiltration after pediatric rmTBI is critical for the development of effective treatment. We hypothesize that pediatric rmTBI alters neuroinflammation through T cell infiltration. We used wild-type (C57BL/6) and T cell knockout (TCRβ

Indexed as

immune cell infiltrationneuroinflammationpediatric repetitive traumatic brain injuryT cells

Identifiers

PMID42564368
PMCPMC13443239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.