ArticleFrontiers in aging neuroscience2026
Ferroptosis-related biomarkers for diagnosis and mechanistic insights into Alzheimer's disease.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Alzheimer's disease (AD) lacks reliable early diagnostic biomarkers and effective disease-modifying therapies. Ferroptosis has been increasingly implicated in AD pathogenesis; however, ferroptosis-related genes with diagnostic and mechanistic relevance remain insufficiently characterized. Methods: Transcriptomic datasets were obtained from the GEO database and analyzed using differential expression analysis and WGCNA, followed by integration with ferroptosis-related gene sets. Key targets were identified through PPI networks and machine learning approaches, including LASSO regression and random forest. A diagnostic model was constructed and its discriminative performance was assessed across independent datasets by cohort-specific refitting. Functional roles were explored using GSEA, and experimental validation was conducted by qPCR in Aβ-treated PC12 cells. Potential therapeutic compounds were predicted using the CMAP database. Results: A total of 52 ferroptosis-related candidate genes were identified. Among these, three genes, Conclusion: Three ferroptosis-related genes,
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