Evidence map›Paper›PMID 42564270›Full record

ArticleVeterinary record open2026

Minimally processed, human-grade diet alters canine epigenetic ageing: Results from a pilot study.

Aimee Chen, Wei Guo, Janina A Krumbeck, Dan Su, Vincent Michels, Xiaojing Yang

Abstract read
In one paragraph

Article in Veterinary record open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aimee ChenZymo Research Corporation Irvine California USA.
Wei GuoZymo Research Corporation Irvine California USA.
Janina A KrumbeckZymo Research Corporation Irvine California USA.
Dan SuJustFoodForDogs Tustin California USA.
Vincent MichelsJustFoodForDogs Tustin California USA.
Xiaojing YangZymo Research Corporation Irvine California USA.ORCID https://orcid.org/0009-0009-3034-3833

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diet plays a critical role in promoting wellness and longevity in both humans and canines. Epigenetic ageing clocks have emerged as accurate tools for assessing biological ageing and evaluating dietary and lifestyle interventions in humans and mice. Methods: A dog-specific epigenetic ageing clock was developed and validated using buccal swab samples from domestic dogs aged 1.5 and 17 years. The clock exhibited a strong correlation with chronological age in both the training set ( Results: Dogs fed with MPHGF diet exhibited a significant reduction in delta age, decreasing from 2.75 to 1.80 years over 6 months ( Conclusion: This study demonstrates the potential for dietary interventions to influence epigenetic ageing in dogs and provides a practical, quantitative framework for investigating healthy ageing in companion animals.

Indexed as

ageingcanineDNA methylationepigenetic ageepigeneticskibble dietminimally processed diet

Identifiers

PMID42564270
PMCPMC13442920

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.