Evidence map›Paper›PMID 42564233›Full record

ArticleiMeta2026

Single-cell profiling of peripheral blood reveals acute-phase immune dysregulation in human scrub typhus.

Yijia Guo, Yi Niu, Nihui Zhang, Xiao Han, Liyuan Zhang, Yongguo Du, Lifen Han, Xiuying Tian, Zhao Xu, Gaoyu Wang and 4 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in iMeta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yijia GuoHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medicine Hainan Medical University Haikou China.
Yi NiuHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medicine Hainan Medical University Haikou China.
Nihui ZhangSchool of Intelligent Medicine and Technology (Big Data Research Center), Hainan Engineering Research Center for Health Big Data Hainan Medical University Haikou China.
Xiao HanFujian Medical University Mengchao Hepatobiliary Hospital Fuzhou China.
Liyuan ZhangDepartment of Infectious Disease the Second Affiliated Hospital of Hainan Medical University Haikou China.
Yongguo DuDepartment of Infectious Disease the Second Affiliated Hospital of Hainan Medical University Haikou China.
Lifen HanFujian Medical University Mengchao Hepatobiliary Hospital Fuzhou China.
Xiuying TianHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medicine Hainan Medical University Haikou China.
Zhao XuHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medicine Hainan Medical University Haikou China.
Gaoyu WangHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medicine Hainan Medical University Haikou China.
Kwok-Yung YuenState Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, and Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong Special Administrative Region China.
Jasper Fuk-Woo ChanState Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, and Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong Special Administrative Region China.
Dahua XuSchool of Intelligent Medicine and Technology (Big Data Research Center), Hainan Engineering Research Center for Health Big Data Hainan Medical University Haikou China.
Feifei YinHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medicine Hainan Medical University Haikou China.ORCID https://orcid.org/0000-0001-6195-0614

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Integrated single-cell RNA sequencing, spectral flow cytometry, immune-receptor repertoire profiling, and plasma proteomics revealed coordinated peripheral immune remodeling during acute scrub typhus. Patients exhibited expansion of cytotoxic, clonally amplified CD8

Identifiers

PMID42564233
PMCPMC13442654

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.