Evidence map›Paper›PMID 42564177›Full record

ArticleNature. Mental health2026

SSRI/SNRI and long COVID in children and adolescents with neuropsychiatric conditions: a cohort study from the RECOVER Initiative.

Ting Zhou, Bingyu Zhang, Yiwen Lu, Jiajie Chen, Chengxi Zang, Haoyang Li, Josephine Elia, Raghuram Prasad, Jonathan Arnold, Sean N Avedissian and 40 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature. Mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors.

Ting ZhouThe Center for Health Analytics and Synthesis of Evidence, University of Pennsylvania, Philadelphia, PA USA.ORCID 0000-0003-3392-2979
Bingyu ZhangThe Center for Health Analytics and Synthesis of Evidence, University of Pennsylvania, Philadelphia, PA USA.
Yiwen LuThe Center for Health Analytics and Synthesis of Evidence, University of Pennsylvania, Philadelphia, PA USA.
Jiajie ChenThe Center for Health Analytics and Synthesis of Evidence, University of Pennsylvania, Philadelphia, PA USA.
Chengxi ZangDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY USA.ORCID 0000-0002-8244-9551
Haoyang LiDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY USA.
Josephine EliaDepartment of Pediatrics, Nemours Children's Health Delaware, Sydney Kimmel School of Medicine, Philadelphia, PA USA.
Raghuram PrasadDepartment of Child and Adolescent Psychiatry and Behavioral Sciences and Autism Integrated Care Program, Children's Hospital of Philadelphia, Philadelphia, PA USA.
Jonathan ArnoldDivision of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA USA.ORCID 0000-0003-1185-555X
Sean N AvedissianRECOVER Patient, Caregiver, or Community Representative, New York, NY USA.ORCID 0000-0002-0935-6455
L Charles BaileyApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, PA USA.
Michael J BecichDepartment of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA USA.ORCID 0000-0001-5998-8074
Wyatt P BenskenDepartment of Research, OCHIN, Portland, OR USA.
Yuriy BisyukOffice of Research, University Medical Center New Orleans, New Orleans, LA USA.ORCID 0000-0003-2380-4776
H Timothy BunnellBiomedical Research Department, Nemours Children's Hospital, Wilmington, DE USA.
Leah CastroRECOVER Patient, Caregiver, or Community Representative, New York, NY USA.
Elizabeth A ChrischillesDepartment of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA USA.
Dimitri A ChristakisCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA USA.
Lindsay G CowellDepartment of Health Data Science and Biostatistics, O'Donnell School of Public Health, UT Southwestern Medical Center, Dallas, TX USA.
Mollie R CumminsCollege of Nursing, University of Utah, Salt Lake City, UT USA.
Soledad FernandezDepartment of Biomedical Informatics and Center for Biostatistics, Ohio State University, Columbus, OH USA.
Daniel FortCenter for Outcomes Research, Ochsner Health, New Orleans, LA USA.ORCID 0000-0002-3759-4063
Sandy GonzalezNicklaus Children's Hospital, Miami, FL USA.
Sharon J HerringDepartment of Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA USA.
Mady HornigRECOVER Patient, Caregiver, or Community Representative, New York, NY USA.ORCID 0000-0001-7572-3092
Wenke HwangDepartment of Public Health Sciences, Division of Health Services Research, Penn State University College of Medicine, Hershey, PA USA.ORCID 0000-0002-8116-807X
Nita JainRECOVER Patient, Caregiver, or Community Representative, New York, NY USA.ORCID 0000-0002-4197-937X
W Schuyler JonesDuke Clinical Research Institute, Duke University Health System, Durham, NC USA.
David C KaelberCenter for Clinical Informatics Research and Education, The MetroHealth System and the Departments of Internal Medicine, Pediatrics, and Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH USA.ORCID 0000-0001-7855-9515
Kelly KelleherCommunity Health, Nationwide Children's Hospital, Columbus, OH USA.
Rachel KenneyDepartment of Neurology, New York University Grossman School of Medicine, New York, NY USA.
John E LeikaufDepartment of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry and Child Development, Stanford University School of Medicine, Palo Alto, CA USA.ORCID 0000-0001-7364-1106
Rebecca LettsRECOVER Patient, Caregiver, or Community Representative, New York, NY USA.ORCID 0009-0009-4747-7918
Mei LiuDepartment of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, FL USA.
Aaron Thomas MartinezRECOVER Patient, Caregiver, or Community Representative, New York, NY USA.
Heidi T MayIntermountain Medical Center Heart Institute, Salt Lake City, UT USA.
Abu Saleh Mohammad MosaDepartment of Biomedical Informatics and Data Science, University of Alabama at Birmingham, Birmingham, AL USA.ORCID 0000-0002-8956-1466
Nathan M PajorDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH USA.
Suchitra RaoDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO USA.
Amy L SalisburySchool of Nursing, Virginia Commonwealth University, Richmond, VA USA.
Srinivasan SureshDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA USA.
Aparna C SwaminathanDepartment of Medicine, Duke University School of Medicine, Durham, NC USA.
Bradley W TaylorClinical and Translational Science Institute, The Medical College of Wisconsin, Milwaukee, WI USA.
Neena Anne ThomasCenter for Biostatistics, The Ohio State University, Columbus, OH USA.
David A WilliamsDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI USA.
Margot Gage WitvlietRECOVER Patient, Caregiver, or Community Representative, New York, NY USA.
Rainu KaushalDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY USA.
Fei WangDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY USA.ORCID 0000-0001-9459-9461
Christopher B ForrestApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, PA USA.
Yong ChenThe Center for Health Analytics and Synthesis of Evidence, University of Pennsylvania, Philadelphia, PA USA.ORCID 0000-0003-0835-0788

Funding

OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository CoreOT2HL161847 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GROSS, RACHEL SHARON, HORWITZ, LEORA · 2021 to 2025
$651.0M
NHLBI NIH HHS OT2 HL161847
6 · The paper itself

Abstract

Long COVID has been an important health concern in children and adolescents, yet factors associated with its development remain incompletely understood. Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are widely prescribed for pediatric neuropsychiatric conditions and may influence immune and autonomic pathways involved in postinfectious symptoms. Here we show associations between SSRI/SNRI use and long coronavirus disease (COVID)-related outcomes in a retrospective cohort of 110,955 children and adolescents with pre-existing neuropsychiatric conditions across 37 US health systems participating in the National Institutes of Health Researching COVID to Enhance Recovery consortium. SSRI/SNRI use was not associated with clinician-recorded long COVID diagnosis but showed heterogeneous associations with individual symptoms. Lower risks were observed for some symptoms, including fever, chills and hair loss, whereas higher risks were observed for neurological and systemic outcomes, including postural orthostatic tachycardia syndrome, cognitive dysfunction and fatigue. These findings suggest that antidepressant exposure may be associated with differing post-COVID symptom patterns in youth and warrant further investigation.

Indexed as

EpidemiologyPaediatricsPsychiatric disorders

Identifiers

PMID42564177
PMCPMC13442008

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.