Evidence map›Paper›PMID 42564108›Full record

ArticleFrontiers in medicine2026

The use of sivelestat sodium among patients with acute pancreatitis and early organ failure: a single-center retrospective cohort study.

Zongwen Zhang, Xinsen Zou, Yiting Guan, Siyu Zhang, Mingfeng Huang, Hong Lin, Jing Zhou, Lin Gao, Wenjian Mao, Bin Yao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zongwen Zhang *Department of Critical Care Medicine, Center of Severe Acute Pancreatitis (CSAP), Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Xinsen Zou *Department of Intensive Care Unit, Bishan Hospital of Chongqing Medical University, Chongqing, China.
Yiting GuanDepartment of Critical Care Medicine, Center of Severe Acute Pancreatitis (CSAP), Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Siyu ZhangDepartment of Critical Care Medicine, Center of Severe Acute Pancreatitis (CSAP), Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Mingfeng HuangDepartment of Critical Care Medicine, Center of Severe Acute Pancreatitis (CSAP), Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Hong LinDepartment of Critical Care Medicine, School of Medicine, Center of Severe Acute Pancreatitis (CSAP), Southeast University, Nanjing, China.
Jing ZhouDepartment of Critical Care Medicine, Center of Severe Acute Pancreatitis (CSAP), Jinling Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Lin GaoDepartment of Critical Care Medicine, Center of Severe Acute Pancreatitis (CSAP), Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Wenjian MaoDepartment of Critical Care Medicine, Center of Severe Acute Pancreatitis (CSAP), Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Bin YaoDepartment of Intensive Care Unit, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Xiangcheng ZhangDepartment of Intensive Care Unit, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Lu KeDepartment of Critical Care Medicine, Center of Severe Acute Pancreatitis (CSAP), Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Zhihui TongDepartment of Critical Care Medicine, Center of Severe Acute Pancreatitis (CSAP), Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Yuxiu LiuDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Weiqin LiDepartment of Critical Care Medicine, Center of Severe Acute Pancreatitis (CSAP), Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to investigate whether neutrophil elastase inhibitor (sivelestat sodium) was associated with decreased duration of organ failure in patients with acute pancreatitis (AP) and early organ failure. Methods: Between January 2022 and December 2024, patients who were diagnosed with AP and early organ failure were included. The primary outcome was organ failure-free days (OFFD) to Day 14 after admission. Propensity score matching (PSM) analysis was performed to control confounders. Multivariate zero-inflated negative binomial regression model was used to evaluate the association between sivelestat sodium and OFFD. An exploratory mediation analysis was carried out to evaluate whether day 3 C-reactive protein partly accounted for the association. Results: 340 patients were enrolled in this study. After PSM, patients receiving sivelestat sodium had significantly more OFFD than those who did not (median [IQR], 9 [5 to 13] vs. 6 [1 to 10], Conclusion: Sivelestat sodium use was associated with more organ failure-free days in patients with AP and early organ failure, particularly in those with respiratory failure. These findings require confirmation in future prospective randomized trials.

Indexed as

acute pancreatitisearly organ failureinhibitorneutrophil elastasesivelestat sodium

Identifiers

PMID42564108
PMCPMC13441825

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.