ArticleAnnals of the Child Neurology Society2025
Fenfluramine: An Uncommon Cause of False Positive Urine Drug Testing: A Case Report.
Article in Annals of the Child Neurology Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Fenfluramine is an antiseizure medication approved by the Food and Drug Administration for the treatment of Dravet syndrome in patients older than 2 years. Fenfluramine is an amphetamine derivative. It cross-reacts with amphetamines in urine drug screen immunoassays. Patient Presentation: A 2-year-old patient with Dravet syndrome had a cardiorespiratory arrest and tested positive for amphetamines in a urine drug screen, raising concerns of child abuse. Liquid chromatography-mass spectrometry confirmed the presence of fenfluramine but did not detect amphetamines. Conclusion: Fenfluramine can result in a false-positive amphetamine urine drug screen at the recommended dose for Dravet syndrome. Awareness of this potential cross-reactivity can prevent undue child protective services reports, especially in patients at high risk for sudden death.
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