ArticleAnnals of the Child Neurology Society2024
Exaggerated T-wave alternans in children with Angelman syndrome.
Article in Annals of the Child Neurology Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Lower respiratory rate during sleep in children with angelman syndrome compared to age-matched controls.Orphanet journal of rare diseases · 2025Article
- Gelastic spells in Angelman Syndrome, when laughter isn't funny.Epilepsy & behavior reports · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: We aimed to test whether T-wave alternans (TWA), which is a marker of susceptibility to ventricular fibrillation, is abnormal in children with Angelman syndrome (AS) compared with typically developing children (TDC), and whether it can be used as a biomarker of AS. Materials and Methods: Using surface electrocardiogram (ECG), we calculated TWA in AS and compared it between AS and TDC (Wilcoxon rank sum test). We then performed logistic regression to test TWA ability to distinguish AS from TDC. Results: We observed higher TWA in AS than TDC (44 vs. 33 uV, Interpretation: Our findings suggest that ECG in children with AS contains evidence of acquired cardiac abnormality via pathologically increased TWA.
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