Evidence map›Paper›PMID 42563615›Full record

ArticleJACC. Case reports2026

Relapsing-Remitting Perimyocarditis and Emerging Acute Myeloid Leukemia.

Madeline B Zipperer-Giblin, John I Bowman, Nidhi Patel, Debbie Rinde-Hoffman

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Madeline B Zipperer-GiblinDepartment of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA. Electronic address: mbzipperer@usf.edu.
John I BowmanDivision of Cardiovascular Sciences, Department of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA.
Nidhi PatelDivision of Cardiovascular Sciences, Department of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA; Heart and Vascular Institute, Tampa General Hospital, Tampa, Florida, USA.
Debbie Rinde-HoffmanDivision of Cardiovascular Sciences, Department of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA; Heart and Vascular Institute, Tampa General Hospital, Tampa, Florida, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerimyocarditis as an initial manifestation of acute myeloid leukemia (AML) is rare, with fewer than 5 contemporary cases reported. CASE SUMMARY: A 66-year-old man experienced 7 hospitalizations over 3 months for fever, elevated troponin, and inflammatory markers after Coxsackievirus B exposure. Initial cardiac magnetic resonance (CMR), infectious, and hematologic work-ups were unremarkable. Repeat CMR revealed biventricular dysfunction, new lateral wall late gadolinium enhancement, myocardial edema, and a circumferential pericardial effusion. Endomyocardial biopsy confirmed severe lymphocytic myocarditis. The patient failed 2 corticosteroid tapers but improved with colchicine, intravenous immunoglobulin, and anakinra. After cardiac recovery, peripheral blood and bone marrow evaluation revealed AML. DISCUSSION: This case highlights a potential rare dual-etiology mechanism for perimyocarditis involving viral injury and AML-driven inflammatory activation. TAKE-HOME MESSAGE: This case underscores the diagnostic value of serial CMR with biopsy, the role of interleukin-1 blockade and intravenous immunoglobulin in steroid refractory disease, and vigilance for emerging hematologic malignancy.

Indexed as

acute heart failurecancercardiac magnetic resonancereduced ejection fraction

Identifiers

PMID42563615
PMCPMC13689857

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.