Evidence map›Paper›PMID 42563540›Full record

ArticleEuropean journal of neurology2026

Beyond Venous Inflammation: Vessel Wall Imaging of Intracranial Arteries in Neuro-Behçet's Syndrome.

Esra Kochan Kizilkilic, Bora Korkmazer, Nursena Erener, Ahmet Kursat Karaman, Abdullah Arcan, Serdar Arslan, Aksel Siva, Emire Seyahi, Ugur Uygunoglu, Osman Kizilkilic

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Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Esra Kochan KizilkilicDepartment of Neurology, University of Health Sciences, Prof. Dr. Cemil Taşcıoğlu City Hospital, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-2623-2710
Bora KorkmazerDivision of Neuroradiology, Department of Radiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Nursena ErenerDepartment of Neurology, Balikesir Atatürk City Hospital, Balıkesir, Turkey.
Ahmet Kursat KaramanDepartment of Radiology, Sureyyapasa Chest Diseases and Thoracic Surgery Training Hospital, Istanbul, Turkey.
Abdullah ArcanDepartment of Neurology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-4124-9032
Serdar ArslanDivision of Neuroradiology, Department of Radiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Aksel SivaDepartment of Neurology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Emire SeyahiDivision of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Ugur UygunogluDepartment of Neurology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Osman KizilkilicDivision of Neuroradiology, Department of Radiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-6620-8934

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuro-Behçet syndrome (NBS) is a heterogeneous inflammatory disorder in which venous involvement is well recognized, while intracranial arterial pathology remains insufficiently characterized. Conventional luminal imaging methods are limited in detecting early or isolated arterial wall abnormalities. Vessel wall imaging (VWI) may provide additional insights into arterial involvement in NBS.

methodsThirty-nine NBS patients (27 men, 12 women; mean age 38.52 ± 9.54 years) underwent intracranial VWI; 16 were imaged during the attack period and 23 during the attack-free period. A total of 1170 artery segments were systematically evaluated for wall thickening patterns and contrast enhancement. VWI findings were analyzed in relation to imaging timing, radiological subtype, MR angiography findings, and EDSS.

resultsVessel wall involvement was found in 16 patients (41%), mainly in the posterior circulation (81%). Concentric wall thickening without enhancement was the most common pattern (80.48%). Vessel wall involvement was significantly more frequent in patients imaged during the attack period compared with those imaged in the attack-free period (68.8% vs. 21.7%; p = 0.007). Vessel wall enhancement was present only in the attack period (p = 0.022). Notably, higher EDSS scores were significantly associated with multisegmental posterior circulation involvement, particularly when ≥ 3 segments were affected (p = 0.015; p = 0.024).

conclusionIntracranial arterial wall involvement is detectable by VWI in a substantial proportion of NBS patients, predominantly in the posterior circulation with a concentric thickening pattern. These findings suggest that arterial wall pathology may be more common than previously recognized and that VWI provides complementary diagnostic information beyond conventional luminal imaging.

Indexed as

Behcet SyndromeCerebral ArteriesAdultFemaleHumansMagnetic Resonance AngiographyMaleMiddle Agedcerebral vasculitisneuro‐Behçet syndromevessel wall imaging

Identifiers

PMID42563540
PMCPMC13448507

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