ArticleBiomedical chromatography : BMC2026
The Effect of Artemisinin on the Pharmacokinetics of Cyclophosphamide and Its Metabolite in Mice and Its Potential Mechanisms.
Article in Biomedical chromatography : BMC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Effect of Artemisinin on the Pharmacokinetics of Cyclophosphamide and Its Metabolite in Mice and Its Potential Mechanisms.Biomedical chromatography : BMC · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Cyclophosphamide (CP) is a common alkylating anticancer drug. Artemisinin (ART), an antimalarial agent metabolized by hepatic CYP450s, exhibits promising antitumor activity. This study established a rapid and accurate LC-MS/MS method for the quantitative analysis of CP and its metabolite in mouse plasma, as well as to apply this method in assessing how ART influences the pharmacokinetics of CP. Given the instability of 4-OH-CP, 4-keto-CP was selected as a surrogate metabolite for detection. The effect of ART on the mRNA expression and activity of CYP450 enzymes were assessed by RT-qPCR and substrate cocktail assay. The results indicated that CP and 4-keto-CP were linear in the range of 1-2000 and 2-2000 ng/mL, respectively. The accuracy, precision, extraction recovery, stability, and matrix effect of CP and 4-keto-CP are complied with the Bioanalytical Method Validation Guidelines. ART significantly reduced the AUC
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.