ArticleMedical physics2026
TOPAS-nBio simulation of the impact of ultrahigh dose rate and oxygen concentration on the Fenton reaction using the Fricke solution.
Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- TOPAS-nBio simulation of the impact of ultrahigh dose rate and oxygen concentration on the Fenton reaction using the Fricke solution.Medical physics · 2026Article
- Factors Influencing the Biological Effects of FLASH Irradiation.Antioxidants (Basel, Switzerland) · 2025Review
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6 authors.
Funding
Abstract
backgroundPreclinical studies have shown that FLASH radiotherapy (FLASH-RT), delivering radiation in ultrahigh dose rates (UHDR), presents reduced healthy tissue toxicity, while maintaining an iso-effective tumor response compared to conventional radiotherapy (CONV-RT). This combined biological benefit was termed as "FLASH effect." The mechanisms responsible for this effect remain unclear, however, it has been hypothesized that the Fenton reaction which produces PURPOSE: We propose to investigate the influence of radiation delivery parameters including pulse width, dose, dose rate, and initial oxygen concentration on the activation of the Fenton reaction using the Fricke solution. METHODS AND MATERIALS: TOPAS-nBio version 4.0 was used to simulate the radiolysis of the Fricke solution. A cubic water phantom (3 µm side) was irradiated laterally by 300 MeV protons. Irradiation was delivered in pulses of tracks with absorbed doses from 1-40 Gy, or in independent tracks. For ultrahigh dose rate (UHDR), we varied the pulse widths between 10 ns and 10 µs, corresponding to instantaneous dose rates of 10
resultsFor CONV, G(Fe
conclusionsThe observed reduction in G(Fe
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.