ReviewMaternal health, neonatology and perinatology2026
Maternal and fetal outcomes in women with uterine congenital abnormalities: a systematic review and meta-analysis.
Review in Maternal health, neonatology and perinatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundCongenital uterine anomalies (CUA) are structural abnormalities resulting from disrupted Müllerian duct development and have been associated with adverse reproductive and obstetric outcomes. However, the magnitude of these risks and variation across anomaly subtypes remain incompletely defined.
objectivesTo evaluate the association between CUA and adverse maternal and fetal outcomes and to examine subtype-specific risk patterns using contemporary evidence.
methodsWe conducted a systematic review and meta-analysis of studies identified from MEDLINE, Web of Science, and Cochrane CENTRAL. Eligible studies compared women with imaging- or surgically confirmed CUA to those with normal uterine anatomy and reported at least one predefined obstetric outcome. Random-effects meta-analyses were used to estimate pooled odds ratios (ORs) with 95% confidence intervals (CIs). Heterogeneity was assessed using the I
resultsThirty studies comprising over 3.3 million pregnancies were included. Compared with women with normal uterine anatomy, CUA were associated with increased odds of miscarriage (OR 1.45, 95% CI 1.13-1.86), preterm birth < 37 weeks (OR 3.74, 95% CI 1.99-7.02), fetal malpresentation (OR 19.28, 95% CI 6.27-59.24), and caesarean delivery (OR 3.52, 95% CI 1.11-11.09). Heterogeneity ranged from low to high across outcomes (I
conclusionsCongenital uterine anomalies are associated with increased risks of adverse pregnancy outcomes, with distinct subtype-specific patterns. Septate uterus is primarily associated with early pregnancy loss, whereas unicornuate and didelphys uteri are more strongly associated with later gestational complications. These findings support classification of pregnancies complicated by CUA as high risk and highlight the need for tailored antenatal surveillance and subtype-specific clinical management.
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