Synthesis of PbS/CdS/ZnS Core/Shell/Shell Quantum Dots for Multiplexed Shortwave Infrared Imaging.

Amish Patel, Thomas C Bewaale, Ayushmaan Tripathi, Allison M Dennis

Abstract read

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Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Amish PatelDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA.

Thomas C BewaaleDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA.

Ayushmaan TripathiDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA.

Allison M DennisDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA. a.dennis@northeastern.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This chapter describes a systematic approach for synthesizing high-quality lead sulfide/cadmium sulfide/zinc sulfide (PbS/CdS/ZnS) core/shell/shell quantum dots (QDs) with tunable emission in the shortwave infrared (SWIR) wavelength range (1000-1700 nm). This protocol details the synthesis of three distinct QD formulations with emission peaks at approximately 1150, 1250, and 1515 nm, enabling multiplexed in vivo imaging applications. The synthetic route involves three key steps: (1) size-controlled synthesis of PbS cores through hot injection precipitation, (2) formation of a CdS shell through cation exchange, and (3) deposition of a ZnS outer shell using a low-temperature single-source precursor approach to enhance stability while preserving optical properties. The protocol ends with a postsynthetic surface treatment to enhance quantum yield. These QDs exhibit excellent brightness, narrow emission linewidths, and superior stability compared to conventional SWIR emitters, making them ideal for deep-tissue, multiplexed imaging applications.

Indexed as

Cadmium CompoundsLeadQuantum DotsSulfidesZinc CompoundsAnimalsInfrared RaysCadmium Compoundscadmium sulfideLeadlead sulfideSulfidesZinc Compoundszinc sulfideBioimagingCation exchangeCdSCore/shell/shellLow-temperature shellingMultiplex imagingNanoparticle stabilityPbSSize controlZnS

Identifiers

PMID42563047

DOI10.1021/ja400948t

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.