Evidence map›Paper›PMID 42563033›Full record

ArticleNature neuroscience2026

Neuroligin-3-CSPG4 interaction maintains oligodendrocyte precursor cell progenitor state and promotes glioma proliferation through mechanotransduction.

Yoon Seok Kim, Shawn M Gillespie, Anna C Geraghty, Belgin Yalçın, Alexis English Ivec, Aerin Yang, Rebecca Mancusi, Jared Hysinger, James Reed, Richard Drexler and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yoon Seok Kim *Department of Neurology, Stanford University, Stanford, CA, USA. yoon.kim@epfl.ch.ORCID http://orcid.org/0000-0003-3332-0652
Shawn M Gillespie *Department of Neurology, Stanford University, Stanford, CA, USA.
Anna C GeraghtyDepartment of Neurology, Stanford University, Stanford, CA, USA.
Belgin YalçınDepartment of Neurology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9689-9062
Alexis English IvecDepartment of Neurology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8369-3225
Aerin YangDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-8704-0288
Rebecca MancusiDepartment of Neurology, Stanford University, Stanford, CA, USA.
Jared HysingerDepartment of Neurology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2413-6255
James ReedDepartment of Neurology, Stanford University, Stanford, CA, USA.
Richard DrexlerDepartment of Neurology, Stanford University, Stanford, CA, USA.
Michael QuezadaDepartment of Neurology, Stanford University, Stanford, CA, USA.
Karen MalaconDepartment of Neurology, Stanford University, Stanford, CA, USA.
Pamelyn WooDepartment of Neurology, Stanford University, Stanford, CA, USA.
Youkyeong Gloria ByunDepartment of Neurology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4669-0855
Christopher MountDepartment of Neurology, Stanford University, Stanford, CA, USA.
Mable LamDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Yuan PanDepartment of Neurology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9465-8289
J Bradley ZucheroDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Jacqueline TrotterInstitute of Developmental Biology and Neurobiology, Department of Biology, Johannes Gutenberg-University of Mainz, Mainz, Germany.
Michelle MonjeDepartment of Neurology, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.ORCID http://orcid.org/0000-0002-3547-237X

Funding

Targeting the Vasular SystemP50CA165962 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Tracy T Batchelor · 2013 to 2026
$33.5M
Targeting the neuronal microenvironment in glioblastomaU19CA264504 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Michelle Monje-Deisseroth · 2021 to 2026
$6.4M
Neuronal Regulation of Low-Grade GliomagenesisR01CA258384 · NCI · STANFORD UNIVERSITY · PI David H Gutmann, Michelle Monje-Deisseroth · 2022 to 2026
$3.1M
Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RR210085ChadTough Foundation (Chad Tough Foundation) N/AGatsby Charitable Foundation N/ANCI NIH HHS P50 CA165962NCI NIH HHS R01 CA258384NCI NIH HHS U19 CA264504U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P50CA165962, R01CA258384, U19CA264504
6 · The paper itself

Abstract

Glioma pathophysiology is robustly regulated by interactions with neurons. Key to these interactions is the role of neuroligin-3 (NLGN3), a synaptic adhesion molecule shed in response to neuronal activity that functions as a paracrine factor crucial for glioma growth. Here we elucidate the mechanistic pathway whereby shed NLGN3 interacts with glioma and their normal glial counterparts. NLGN3 binds to chondroitin sulfate proteoglycan 4 (CSPG4, also known as NG2) on both glioma and healthy oligodendrocyte precursor cells (OPCs), facilitating CSPG4 shedding by ADAM10. NLGN3-CSPG4 interactions alter membrane tension, thereby activating mechanotransducers, primarily PIEZO1, leading to membrane depolarization and subsequent ADAM10-mediated CSPG4 shedding. The NLGN3-CSPG4-PIEZO1 pathway maintains OPCs in an undifferentiated, stem-like state and promotes glioma proliferation, underscoring its dual roles in healthy and malignant contexts.

Indexed as

Brain NeoplasmsCell Adhesion Molecules, NeuronalCell ProliferationChondroitin Sulfate ProteoglycansGliomaMechanotransduction, CellularMembrane ProteinsNerve Tissue ProteinsNeuroliginsOligodendrocyte Precursor CellsProteoglycansADAM10 ProteinAmyloid Precursor Protein SecretasesAnimalsChondroitin Sulfate Proteoglycan 4HumansADAM10 ProteinAmyloid Precursor Protein SecretasesCell Adhesion Molecules, NeuronalChondroitin Sulfate Proteoglycan 4Chondroitin Sulfate ProteoglycansCSPG4 protein, humanMembrane ProteinsNerve Tissue Proteinsneuroligin 3NeuroliginsProteoglycans

Identifiers

PMID42563033
PMCPMC13633123

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.