Evidence map›Paper›PMID 42563023›Full record

ArticleSleep & breathing = Schlaf & Atmung2026

Polysomnographic arousal index and periodic limb movement index in patients undergoing coronary artery bypass grafting: an exploratory case-comparison study.

Jaidaa Mekky, Henyah W Dardir, Kaitlyn Malek, Ahmed Adham R Elsayed, Sherif W Ayad, Ismail Ramadan, Horeya Saadallah, Marc D Basson

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jaidaa MekkyNeuropsychiatry Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Henyah W DardirCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Kaitlyn MalekCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Ahmed Adham R ElsayedCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Sherif W AyadCardiology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Ismail RamadanNeuropsychiatry Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Horeya SaadallahNeuropsychiatry Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Marc D BassonCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH, 44272, USA. mbasson@neomed.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeObstructive sleep apnea (OSA) is a known risk factor for coronary artery disease (CAD), but its phenotypic variations and their impact on cardiovascular risk remain unclear. Recent studies suggest that a high periodic limb movement index (PLMI) and a high arousal index OSA phenotype may contribute to cardiovascular disease. This study aims to assess the association between this phenotype and CAD in patients undergoing preprocedural screening for coronary artery bypass grafting (CABG).

methodsThis case-comparison study analyzed a prospective adult patient group undergoing polysomnography before CABG, compared to an age- and gender-matched retrospective group undergoing polysomnography for employment screening. Sleep parameters, including PLMI, arousal index, apnea-hypopnea index (AHI), and sleep onset latency, were assessed. Statistical analysis, including chi-square tests, Fisher's exact test, and multivariable logistic regression, was conducted to evaluate associations between sleep disturbances and CAD.

resultsCAD patients had significant differences in the amount of abnormal PLMI, arousal index, and AHI values compared to the non-CAD group (p = 0.0002, p = 0.002, and p = 0.015, respectively). Multivariable regression identified high PLMI and arousal index as the strongest associations of CAD.

conclusionA high PLMI/high arousal index OSA phenotype may increase cardiovascular risk. Identifying high-risk OSA phenotypes could improve early CAD screening and intervention strategies. Further research is needed to explore underlying mechanisms.

Indexed as

ArousalCoronary Artery BypassCoronary Artery DiseaseNocturnal Myoclonus SyndromePolysomnographySleep Apnea, ObstructiveAgedCase-Control StudiesFemaleHumansMaleMiddle AgedProspective StudiesRetrospective StudiesRisk FactorsCABGCADObstructive sleep apneaSleep disorders

Identifiers

PMID42563023
PMCPMC13447470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.