Evidence map›Paper›PMID 42562993›Full record

ArticleGene therapy2026

A gene therapy approach to prevent dilated intercellular space, a hallmark of gastroesophageal reflux disease.

Gillian M Schiralli Lester, Jing Huang, Michael Barravecchia, Lananh N Whigham, Jada M Hooker, Karen L de Mesy Bentley, Jennifer L Young, Zhongren Zhou, David A Dean

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gillian M Schiralli LesterDivision of Neonatology, Dept. of Pediatrics, University of Rochester, Rochester, NY, USA.
Jing HuangDepartment of Pathology & Laboratory Medicine, Robert Wood Johnson Medical School and New Jersey Medical School, New Brunswick, NJ, USA.
Michael BarravecchiaDivision of Neonatology, Dept. of Pediatrics, University of Rochester, Rochester, NY, USA.
Lananh N WhighamDivision of Neonatology, Dept. of Pediatrics, University of Rochester, Rochester, NY, USA.
Jada M HookerDivision of Neonatology, Dept. of Pediatrics, University of Rochester, Rochester, NY, USA.
Karen L de Mesy BentleyDepartment of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, USA.
Jennifer L YoungDivision of Neonatology, Dept. of Pediatrics, University of Rochester, Rochester, NY, USA.
Zhongren ZhouDepartment of Pathology & Laboratory Medicine, Robert Wood Johnson Medical School and New Jersey Medical School, New Brunswick, NJ, USA. zz442@rwjms.rutgers.edu.
David A DeanDivision of Neonatology, Dept. of Pediatrics, University of Rochester, Rochester, NY, USA. David_dean@urmc.rochester.edu.ORCID 0000-0001-7748-8073

Funding

Gene therapy for GERD-associated esophageal epithelial barrier dysfunctionR01DK120680 · NIDDK · UNIVERSITY OF ROCHESTER · PI DEAN, DAVID A, ZHOU, ZHONGREN · 2020 to 2022
$1.6M
NIDDK NIH HHS R01 DK120680U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HLU.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK120680
6 · The paper itself

Abstract

The incidence of esophageal disease ranging from gastroesophageal reflux disease (GERD) to cancer has dramatically risen over the last 10 years. However, there have been limited descriptions of effective gene delivery methods for the esophagus. We developed a simple and effective electroporation-based gene delivery procedure to target the distal esophagus in living animals. We have used this approach to prevent formation of dilated intercellular space (DIS), a pathological feature of GERD, which is characterized by disruption of tight junctions and loss of epithelial barrier function. We found that tight junction proteins and the Na

Indexed as

Gastroesophageal RefluxGenetic TherapySodium-Potassium-Exchanging ATPaseAnimalsDisease Models, AnimalElectroporationEsophagusExtracellular SpaceGene Transfer TechniquesHumansRabbitsRatsTight JunctionsSodium-Potassium-Exchanging ATPase

Identifiers

PMID42562993
PMCPMC13585548

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.