Evidence map›Paper›PMID 42562904›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Risk factors for thyroid gland invasion in advanced laryngeal cancer: implications for selective thyroidectomy.

Marlinda Adham, Thalia Mufida, Syahrial Hutauruk, Reyhan Eddy Yunus, Yayi Dwina Billianti Susanto, Trevino Pakasi

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Toward evidence-based thyroid preservation in total laryngectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Marlinda AdhamDepartment of ENT, Faculty of Medicine, Universitas Indonesia - Dr., Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia. marlinda.adham@yahoo.com.ORCID http://orcid.org/0000-0003-1135-4384
Thalia MufidaDepartment of ENT, Faculty of Medicine, Universitas Indonesia - Dr., Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
Syahrial HutaurukDepartment of ENT, Faculty of Medicine, Universitas Indonesia - Dr., Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
Reyhan Eddy YunusDepartment of Radiology, Faculty of Medicine, Universitas Indonesia Dr, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
Yayi Dwina Billianti SusantoDepartment of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
Trevino PakasiDepartment of Community Medicine, Faculty of Medicine, Universitas Indonesia, Kota Depok, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe prevalence of thyroid gland invasion in advanced-stage laryngeal carcinoma requiring total laryngectomy remains inconsistent across published literature, and consensus guidelines for prophylactic thyroidectomy are lacking, resulting in potential overtreatment. This study aimed to determine the frequency of thyroid invasion and identify independent predictive factors in patients with advanced laryngeal carcinoma undergoing total laryngectomy at a tertiary referral center.

methodsA cross-sectional analytical study was conducted on 139 patients who underwent total laryngectomy with thyroidectomy between 2020 and 2025 at Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. Bivariate analyses identified candidate predictors, followed by multivariate logistic regression to determine independent risk factors for histopathologically confirmed thyroid invasion.

resultsThyroid invasion was histopathologically confirmed in 25 of 139 cases (18%). Bivariate analysis revealed significant associations with diagnosis-to- treatment interval, tracheostomy-to-laryngectomy interval, T stage, thyroid car- tilage invasion, and radiologic evidence of thyroid invasion. Multivariate logistic regression identified two independent predictors: tracheostomy-to-laryngectomy interval > 2 months (aOR 7.40, 95% CI 1.2 - 44.1, p < 0.028) and radiologic thyroid invasion (aOR 55.3, 95% CI 14.3-212.9, p < 0.001).

conclusionsIn this cohort, 82% of patients underwent thyroidectomy without pathologic evidence of invasion. The tracheostomy-to-laryngectomy interval and radiologic thyroid invasion are independent predictors of histopathologic thyroid invasion in advanced laryngeal carcinoma. These findings support the development of more selective, evidence-based criteria for thyroidectomy during total laryngectomy, potentially reducing unnecessary surgical morbidity.

Indexed as

Laryngeal carcinomaPredictive factorsThyroidectomyThyroid gland invasionTotal laryngectomy

Identifiers

PMID42562904

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.