ReviewCommunications biology2026
Long-term major histocompatibility complex class I suppression in astronauts and clinical implications.
Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spaceflight can disrupt astronaut immunity, including sustained downregulation of Major Histocompatibility Complex (MHC) class I genes across missions ranging from the three-day Inspiration4 flight to long-duration International Space Station stays. MHC class I downregulation is a known mechanism of immune evasion in cancer and viral infection, potentially increasing health risks during and after spaceflight. The underlying mechanisms, clinical implications and therapeutic options remain underexplored. This Perspective discusses long-term risks associated with astronaut MHC class I suppression, proposes future research directions and outlines therapeutic approaches with broader relevance to related health challenges on Earth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.