ArticleScientific reports2026
Development and characterization of a sustainable bacterial cellulose/collagen composite membrane for enhanced wound healing and tissue regeneration applications.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to develop a bacterial cellulose/collagen composite membrane (BC/COL) for its wound-healing ability using collagen extracted from the scales of golden grouper (Epinephelus coioides), thus providing a sustainable derived source. BC was produced by Acetobacter pasteurianus PV549389 under static fermentation, and culture conditions were optimized using response surface methodology. ANOVA analysis confirmed the significance of the model (F = 5.09, p = 0.044), identifying optimal conditions of 21.3 g/L glucose, 4.9 g/L peptone, and pH 6.7, yielding a maximum BC of 3.99 g/L. The developed BC/COL membrane exhibited a uniform morphology, enhanced thermal stability, and clear functional group interactions, confirming the successful integration of the polymer. The biological performance of BC/COL membrane was evaluated through in vitro scratch assays and in vivo excisional wound-healing studies in rats. The BC/COL membrane exhibited a safe profile toward dermal fibroblasts, significantly enhancing cell migration (91%) and accelerating wound-healing rates (3.03%/h and 1.91%/h after 24 and 48 h, respectively) compared with the control and collagen-treated groups. Histological and histomorphometric analyses revealed enhanced tissue regeneration in BC/COL-treated wounds, characterized by increased epidermal thickness (97.5 μm), elevated collagen deposition (59.4%), improved epidermal organization, and reduced inflammatory cell infiltration compared with the untreated control group. This study shows that BC/COL membrane effectively provides a sustainable and biocompatible wound dressing material, with strong potential for clinical application.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.