Evidence map›Paper›PMID 42562838›Full record

ArticleCommunications chemistry2026

Structure-based macrocyclization of α-ketoamides leads to potent inhibitors of coronaviral and enteroviral proteases.

Ravi Kumar Akula, Haifa El Kilani, Alina Metzen, Sanjata Joshi, Hilal Durmaz, Robin Veenstra, Judith Röske, Daniel L Hurdiss, Frank J M Van Kuppeveld, Katharina Rox and 2 more

Abstract read
In one paragraph

Article in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ravi Kumar Akula *Department of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Haifa El Kilani *Institute of Molecular Medicine, University of Lübeck, Lübeck, Germany. haifa.elkilani@helmholtz-hzi.de.ORCID http://orcid.org/0000-0003-4084-3582
Alina MetzenDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Sanjata JoshiInstitute of Molecular Medicine, University of Lübeck, Lübeck, Germany.
Hilal DurmazDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Robin VeenstraVirology section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Judith RöskeInstitute of Molecular Medicine, University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0009-0001-7776-9729
Daniel L HurdissVirology section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-3834-5808
Frank J M Van KuppeveldVirology section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Katharina RoxDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.ORCID http://orcid.org/0000-0002-8020-1384
Rolf HilgenfeldInstitute of Molecular Medicine, University of Lübeck, Lübeck, Germany.
Mark BrönstrupDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany. mark.broenstrup@helmholtz-hzi.de.ORCID http://orcid.org/0000-0002-8971-7045

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral proteases represent validated targets for direct-acting antivirals and the treatment of associated infections. In co-crystal structures of M

Identifiers

PMID42562838
PMCPMC13448699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.