ReviewJournal of the American Academy of Orthopaedic Surgeons. Global research & reviews2026
Studying the Natural History of the Knee Joint.
Review in Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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Abstract
By the time the orthopaedic surgeon sees a patient with symptomatic knee osteoarthritis, the disease has already progressed to an advanced stage. As a result, studying the full natural history of the knee is especially difficult. A few large longitudinal cohorts, the Osteoarthritis Initiative and Multicenter Osteoarthritis Study in particular, provide the bulk of the data for most extant studies. In this review, we report on the current state of knowledge regarding the study of the natural history of the knee, including the difficulties of natural history research, the tools used to assess knee osteoarthritis, the major longitudinal studies in knee osteoarthritis, and the ability of early interventions to modify natural history. In addition, we will preview what is possible using artificial intelligence and newer large longitudinal cohorts.
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