Evidence map›Paper›PMID 42561954›Full record

ArticleCell genomics2026

Single-library chromosome-scale diploid assemblies of vole genomes resolve a species-specific duplication implicated in pair bonding.

Mohamed Abuelanin, Gulhan Kaya, Juniper A Lake, Christine Lambert, Melody V Wu, Kristen M Berendzen, Jonathan Wood, Ksenia Krasheninnikova, Nancy G Solomon, Zoe R Donaldson and 6 more

Abstract read
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In one paragraph

Article in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Mohamed AbuelaninGenome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, University of California, Davis, Davis, CA 95616, USA.
Gulhan KayaGenome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, University of California, Davis, Davis, CA 95616, USA.
Juniper A LakePacific Biosciences, Menlo Park, CA 94025, USA.
Christine LambertPacific Biosciences, Menlo Park, CA 94025, USA.
Melody V WuCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Kristen M BerendzenDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA, USA.
Jonathan WoodWellcome Sanger Institute, Hinxton CB10 1SA, UK.
Ksenia KrasheninnikovaWellcome Sanger Institute, Hinxton CB10 1SA, UK.
Nancy G SolomonDepartment of Biology, Miami University of Ohio, Miami, OH, USA.
Zoe R DonaldsonDepartment of Molecular, Cellular, and Developmental Biology, Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Karen L BalesDepartments of Psychology, Neurobiology, Physiology, and Behavior and California National Primate Research Center, University of California, Davis, Davis, CA, USA.
Kerstin HoweWellcome Sanger Institute, Hinxton CB10 1SA, UK.
Jonas KorlachPacific Biosciences, Menlo Park, CA 94025, USA.
Devanand ManoliDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA, USA.
Jessica TollkuhnCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Megan Y DennisGenome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, University of California, Davis, Davis, CA 95616, USA. Electronic address: mydennis@ucdavis.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comparing prairie voles (Microtus ochrogaster), a species that forms lasting pair bonds and exhibits biparental care, with meadow voles (Microtus pennsylvanicus), a non-monogamous species showing maternal care only, provides a framework to examine the genomic basis of behavioral divergence over short evolutionary time. Here, we develop a simplified assembly approach combining PacBio HiFi and CiFi sequencing in a single library and run, producing high-quality contiguous chromosome-scale diploid prairie and meadow vole genomes (2.3 Gbp). Comparative analysis reveals substantial differences, including near-complete Y chromosome divergence and a prairie-vole-specific duplication of Avpr1a, a vasopressin receptor gene implicated in social bonding and autism in humans. These extensive genomic changes suggest rapid chromosome evolution as a driver of the dramatic Microtus radiation, generating ∼60 vole species in >2 million years. This single-library approach facilitates a simplified and more affordable assembly workflow, producing near-complete genomes of diverse species using one sequencing platform.

Indexed as

3Cchromosome conformation captureCiFigenome assemblyHiFilong-read sequencingmate-pair bondingmeadow voleprairie volevasopressin

Identifiers

PMID42561954

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.