Evidence map›Paper›PMID 42561944›Full record

ArticleStem cell reports2026

Cortical organoids reveal human-specific role of METTL5 in neurodevelopment via regulation of CHCHD2.

Elena M Turkalj, Gugene Kang, Isabelle Liu, Mariami Kuljanishvili, Neda Keyhanvar, Michael C Oldham, Caroline Vissers

Abstract read
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Elena M TurkaljDevelopmental & Stem Cell Biology, UCSF, San Francisco, CA, USA.
Gugene KangDevelopmental & Stem Cell Biology, UCSF, San Francisco, CA, USA.
Isabelle LiuDepartment of Biochemistry and Biophysics, UCSF, San Francisco, CA, USA.
Mariami KuljanishviliDepartment of Biochemistry and Biophysics, UCSF, San Francisco, CA, USA.
Neda KeyhanvarDepartment of Biochemistry and Biophysics, UCSF, San Francisco, CA, USA.
Michael C OldhamDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Caroline VissersDepartment of Biochemistry and Biophysics, UCSF, San Francisco, CA, USA. Electronic address: caroline.vissers24@gmail.com.

Funding

UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Illumina NovaSeq 6000 Sequencing SystemS10OD028511 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOW, ERIC D · 2020 to 2020
$583k
NIDDK NIH HHS P30 DK098722NIH HHS S10 OD028511
6 · The paper itself

Abstract

Methyltransferase-like 5 (METTL5) catalyzes N6-methyladenosine (m

Indexed as

Cerebral CortexMethyltransferasesMitochondrial ProteinsOrganoidsTranscription FactorsCell DifferentiationCell ProliferationEpitranscriptomeHumansInduced Pluripotent Stem CellsNeural Stem CellsNeurodevelopmentNeurogenesisRNA MethylationMethyltransferasesMitochondrial ProteinsTranscription FactorsCHCHD2epitranscriptomicsm6AMETTL5neural stem cellneurogenesisorganoidsrRNA

Identifiers

PMID42561944
PMCPMC13555456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.