Evidence map›Paper›PMID 42561942›Full record

ReviewStem cell reports2026

The transformative impact of stem cell core facilities in biomedical research.

Barbara Corneo, Giovanni Faga, Inês Figueira, Jacopo Zasso, Wenli Yang, Katrin Neuman, Pia A Johansson, Lyn Healy, Laurence M Daheron, Melanie Generali and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Barbara CorneoStem Cell Core, Columbia University, New York, NY, USA. Electronic address: bc2599@cumc.columbia.edu.
Giovanni FagaNational Facility for Genome Engineering and Disease Modelling, Human Technopole, Viale Rita Levi-Montalcini 1, 20157 Milano, Italy.
Inês FigueiraiNOVA4Health, NOVA Institute for Medical Systems Biology, NIMSB, Universidade Nova de Lisboa, 1099-085 Lisboa, Portugal; iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal.
Jacopo ZassoNational Facility for Genome Engineering and Disease Modelling, Human Technopole, Viale Rita Levi-Montalcini 1, 20157 Milano, Italy.
Wenli YangiPSC Core Facility, University of Pennsylvania, Philadelphia, PA, USA.
Katrin NeumanStem Cell Engineering Facility, Center for Regenerative Therapies Dresden (CRTD), TUD Dresden University of Technology, Fetscherstraße 105, 01309 Dresden, Germany.
Pia A JohanssonCell and Gene Technologies Core, Lund Stem Cell Centre, Lund University, Lund, Sweden.
Lyn HealyDepartment of Medical & Molecular Genetics, Faculty of Life Sciences & Medicine, School of Basic & Medical Biosciences, Kings College London, London, UK.
Laurence M DaheronHarvard Stem Cell Institute iPS Core Facility, Cambridge, MA, USA.
Melanie GeneraliInstitute for Regenerative Medicine (IREM), University of Zurich, 8952 Schlieren, Switzerland.
Ole PlessFraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany.
Ras TrokovicResearch Programs Unit, Stem Cells and Metabolism and Biomedicum Stem Cell Centre, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Laurent DavidNantes Université, CHU Nantes, Inserm, and CR2TI, CNRS, Inserm, BioCore, 44000 Nantes, France.
Mehrnaz GazhviniErasmus MC iPS Core Facility, Erasmus University Medical Center, Rotterdam, the Netherlands.
Laura Batlle-MoreraTissue Engineering Unit, Center for Genomic Regulation (CRG), Barcelona, Spain. Electronic address: laura.batlle@crg.eu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past three decades, advances in human pluripotent stem cell (hPSC) technologies, including induced pluripotent stem cells, gene editing, and 2D/3D models, have transformed biomedical research. These powerful tools have revolutionized disease modeling, drug discovery, and the development of advanced therapy medicinal products (ATMPs), while driving the establishment of stem cell core facilities. By providing specialized expertise, standardized workflows, and access to advanced technologies, these facilities support both fundamental and translational research, promote rigor and reproducibility, and foster collaboration. This manuscript highlights their role as hubs of excellence and discusses current challenges and future opportunities for the global stem cell community.

Indexed as

Biomedical ResearchPluripotent Stem CellsAnimalsGene EditingHumansInduced Pluripotent Stem CellsStem Cell ResearchTranslational Research, Biomedical

Identifiers

PMID42561942
PMCPMC13555415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.