Evidence map›Paper›PMID 42561938›Full record

ArticleStem cell reports2026

Suidae iPSC-derived macrophages as models for investigating susceptibility and resilience to African swine fever virus.

Tom M Watson, Lynnette C Goatley, Stephen Meek, Lel Eory, Sylvia Kohler, Nicholas Berkley, Sofia Sternberg, Melany Jackson, Amy Findlay, Isabella Hoskins and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Tom M WatsonThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Lynnette C GoatleyThe Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK.
Stephen MeekThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Lel EoryThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Sylvia KohlerCollection of Cell Lines in Veterinary Medicine, Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald, Insel Riems, Germany.
Nicholas BerkleyAnimal and Plant Health Agency, Virology, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK.
Sofia SternbergThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Melany JacksonThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Amy FindlayThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Isabella HoskinsThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Simon GirlingRoyal Zoological Society of Scotland, 134 Corstorphine Road, Edinburgh EH12 6TS, UK.
Joseph MeeRoslin Technologies Ltd, Roslin Innovation CentreEaster Bush Campus, Edinburgh EH25 9RG, UK.
Alan L ArchibaldThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Finn GreyThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Falko SteinbachAnimal and Plant Health Agency, Virology, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK.
Helen CrookeAnimal and Plant Health Agency, Virology, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK.
Christopher L NethertonThe Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK. Electronic address: christopher.netherton@pirbright.ac.uk.
Tom BurdonThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK. Electronic address: tom.burdon@roslin.ed.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

African swine fever virus (ASFV) causes a lethal hemorrhagic fever in pigs, and spread of this disease threatens many pig species (Suidae) globally. By contrast, ASFV infections in the natural evolved hosts, warthog and bushpig, are subclinical. The macrophage (Mϕ) is the primary target of ASFV, and species-dependent responses in Mϕs are presumed to influence disease susceptibility. In an attempt to model these differences in vitro, we generated transgene-regulated induced pluripotent stem cells (iPSCs) from domestic pig, wild boar, red river hog, and warthog and confirmed that their corresponding iPSC-derived Mϕs (iPSCdMs) supported infection and replication of ASFV. In contrast to the other species, however, warthog iPSCdMs did not induce interferon α upon infection by either virulent or attenuated ASFV. iPSCdMs may therefore represent an experimental system to understand how ASFV infection of Mϕs contributes to disease and aid development of strategies to combat this economically and environmentally devastating pathogen.

Indexed as

African Swine FeverAfrican Swine Fever VirusInduced Pluripotent Stem CellsMacrophagesAnimalsCell DifferentiationDisease SusceptibilitySwineVirus ReplicationAfrican swine fever virusiPSCSuidae

Identifiers

PMID42561938
PMCPMC13555459

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.