Evidence map›Paper›PMID 42561934›Full record

ArticleNeuron2026

Tau-induced mitochondrial reverse electron transport drives neurodegeneration.

Wen Li, Suman Rimal, Sunil Bhurtel, Lucas Yeung, Benjamin G Lu, Lea T Grinberg, Salvatore Spina, Maria Inmaculada Cobos Sillero, William W Seeley, Su Guo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Wen LiDepartment of Pathology, Stanford University School of Medicine, R270 Edwards Building, 300 Pasteur Drive, Stanford, CA 94305, USA.
Suman RimalDepartment of Pathology, Stanford University School of Medicine, R270 Edwards Building, 300 Pasteur Drive, Stanford, CA 94305, USA.
Sunil BhurtelDepartment of Pathology, Stanford University School of Medicine, R270 Edwards Building, 300 Pasteur Drive, Stanford, CA 94305, USA.
Lucas YeungDepartment of Pathology, Stanford University School of Medicine, R270 Edwards Building, 300 Pasteur Drive, Stanford, CA 94305, USA.
Benjamin G LuDepartment of Pathology, Stanford University School of Medicine, R270 Edwards Building, 300 Pasteur Drive, Stanford, CA 94305, USA.
Lea T GrinbergMemory and Aging Center, Department of Neurology, Department of Pathology, University of California, San Francisco, San Francisco, CA 94158, USA.
Salvatore SpinaMemory and Aging Center, Department of Neurology, Department of Pathology, University of California, San Francisco, San Francisco, CA 94158, USA.
Maria Inmaculada Cobos SilleroDepartment of Pathology, Stanford University School of Medicine, R270 Edwards Building, 300 Pasteur Drive, Stanford, CA 94305, USA.
William W SeeleyMemory and Aging Center, Department of Neurology, Department of Pathology, University of California, San Francisco, San Francisco, CA 94158, USA.
Su GuoDepartment of Bioengineering and Therapeutic Sciences, Programs in Human Genetics and Biological Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA.
Bingwei LuDepartment of Pathology, Stanford University School of Medicine, R270 Edwards Building, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address: bingwei@stanford.edu.

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Bradley F Boeve · 2019 to 2026
$120.9M
Early Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Molecular Genetic Analysis of TORC1 and TORC2 Signaling in Neuronal MaintenanceR01NS084412 · NINDS · STANFORD UNIVERSITY · PI Bingwei Lu · 2014 to 2026
$4.9M
Mechanisms of renin-angiotensin signaling in programmed and insult-induced neuronal deathR01NS120219 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUO, SU · 2021 to 2025
$2.0M
Genetic control of neural stem cell homeostasisR37NS083417 · NINDS · STANFORD UNIVERSITY · PI Bingwei Lu · 2024 to 2026
$1.9M
Shared Mechanisms of Tau Toxicity Among Neurodegenerative DiseasesR01AG089752 · NIA · STANFORD UNIVERSITY · PI Bingwei Lu · 2025 to 2026
$1.5M
Reverse electron transport and tauopathyR21AG083863 · NIA · STANFORD UNIVERSITY · PI LU, BINGWEI · 2023 to 2024
$426k
NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG089752NIA NIH HHS R21 AG083863NIA NIH HHS U01 AG057195NIA NIH HHS U19 AG063911NINDS NIH HHS R01 NS084412NINDS NIH HHS R01 NS120219NINDS NIH HHS R37 NS083417
6 · The paper itself

Abstract

Hyperphosphorylation and aggregation of tau are pathological hallmarks of tauopathies. Mitochondrial dysfunction is also a common feature of tauopathies. The mechanistic link between tau abnormalities and mitochondrial dysfunction and its relationship to the physiological function of tau, however, is unclear. Here, we demonstrate that tau regulates mitochondrial reverse electron transport (RET), which produces excess reactive oxygen species (ROS), reduces the NAD

Indexed as

Alzheimer’s diseasecomplex ImitochondriaNAD(+)/NADH ratioNDUFS3phosphorylationreverse electron transportROStautauopathy

Identifiers

PMID42561934
PMCPMC13454983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.