ArticleJournal of behavioral addictions2026
A trans-therapeutic signature of recovery in internet gaming disorder: From shared network reorganization to molecular underpinnings.
Article in Journal of behavioral addictions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Background and aims: A variety of self-regulation interventions have shown efficacy in treating Internet Gaming Disorder (IGD), but their shared and unique neurobiological mechanisms remain unclear. This study aims to identify a common, trans-therapeutic neural signature of recovery and to delineate the specific connectivity fingerprints of five different self-regulation interventions for IGD. Methods: This secondary analysis pooled resting-state fMRI data from 269 individuals with IGD who participated in one of five randomized controlled trials of self-regulation-based interventions: Approach Bias Modification (ApBM), Retrieval-Aversive Conditioning (R-AC), Progressive Aerobic Training (PAT), face-to-face Mindfulness Meditation (MM), and a Digital (online) mindfulness intervention. Participants were diagnosed with IGD according to DSM-5. Partial Least Squares (PLS) regression was used to identify a shared connectivity pattern associated with clinical improvement and similarity network fusion to define intervention-specific connectivity fingerprints. Imaging-transcriptomic analysis was further used to explore the molecular correlates. Results: All interventions were associated with significant reductions in IGD severity. PLS analysis identified a shared connectivity pattern predictive of treatment response, characterized by a rebalancing of Subcortical Network (SCN) connectivity along the sensorimotor-association axis. This shared pattern was linked to gene expression profiles related to cellular stress and neuroplasticity. Each intervention also induced a unique connectivity fingerprint, targeting distinct neural circuits. Discussion and Conclusions: Diverse self-regulation interventions for IGD converge on a shared therapeutic pathway involving the large-scale reorganization of cortico-subcortical circuits. These findings identify a robust neurobiological phenotype of recovery, offering a potential biomarker for treatment response and a target for future circuit-based therapies.
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