Evidence map›Paper›PMID 42560631›Full record

ArticleImmunologic research2026

FUNDC1-mediated mitochondrial quality control protects against immune checkpoint inhibitor-associated cardiac injury.

Nengfeng Zhang, Yao Zhou, Hailing Li, Haiyun Liu

Abstract read
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In one paragraph

Article in Immunologic research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nengfeng ZhangDepartment of Cardiology, The Second People's Hospital of Huai'an/The Affiliated Huai'an Hospital of Xuzhou Medical University, 60# Huaihai South Road, Qingjiangpu District, Huai'an City, 223002, Jiangsu Province, China.
Yao ZhouDepartment of Cardiology, The Second People's Hospital of Huai'an/The Affiliated Huai'an Hospital of Xuzhou Medical University, 60# Huaihai South Road, Qingjiangpu District, Huai'an City, 223002, Jiangsu Province, China.
Hailing LiDepartment of Cardiology, The Second People's Hospital of Huai'an/The Affiliated Huai'an Hospital of Xuzhou Medical University, 60# Huaihai South Road, Qingjiangpu District, Huai'an City, 223002, Jiangsu Province, China.
Haiyun LiuDepartment of Cardiology, The Second People's Hospital of Huai'an/The Affiliated Huai'an Hospital of Xuzhou Medical University, 60# Huaihai South Road, Qingjiangpu District, Huai'an City, 223002, Jiangsu Province, China. haiyunliu0126@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) targeting PD-1 are effective cancer therapies but can cause severe myocarditis. The molecular mechanisms linking PD-1 blockade to cardiomyocyte damage are incompletely understood. We established a murine model of anti-PD-1-associated cardiac injury and used human AC16 cardiomyocytes in co-culture with CD8

Indexed as

Immune Checkpoint InhibitorsMembrane ProteinsMitochondriaMitochondrial ProteinsMyocytes, CardiacAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, KnockoutMitophagyProgrammed Cell Death 1 ReceptorFUNDC1 protein, mouseImmune Checkpoint InhibitorsMembrane ProteinsMitochondrial ProteinsProgrammed Cell Death 1 ReceptorCardiotoxicityFibrosisFUNDC1Immune checkpoint inhibitorMitophagyMyocarditis

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.