Evidence map›Paper›PMID 42560592›Full record

ArticleAnnals of biomedical engineering2026

Computational Optimization of the Orbital Shaker Operational Parameters in Endothelial Mechanobiology.

Erik Muñoz, Nikolaos M Tsoukias, B Rita Alevriadou, Asad Mirza

Abstract read
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Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Erik MuñozVascular Mechanobiology Laboratory, Department of Biomedical Engineering, University at Buffalo-SUNY, Buffalo, NY, 14260, USA.ORCID http://orcid.org/0000-0003-3783-8133
Nikolaos M TsoukiasDepartment of Biomedical Engineering, Florida International University, Miami, FL, 33174, USA.ORCID http://orcid.org/0000-0002-5164-9577
B Rita AlevriadouVascular Mechanobiology Laboratory, Department of Biomedical Engineering, University at Buffalo-SUNY, Buffalo, NY, 14260, USA. alevri@buffalo.edu.ORCID http://orcid.org/0000-0003-1897-755X
Asad MirzaDepartment of Biomedical Engineering, Florida International University, Miami, FL, 33174, USA. amirza@fiu.edu.ORCID http://orcid.org/0000-0003-4515-2203

Funding

Cerebral Microvascular Signaling and Neurovascular Coupling: An Integrated Approach to Investigate VCIDR01NS119971 · NINDS · FLORIDA INTERNATIONAL UNIVERSITY · PI TSOUKIAS, NIKOLAOS MICHAEL · 2021 to 2025
$2.6M
Control of Endothelial Mechanotransduction by the Mitochondrial Ca2+ Uniporter: Implications for AtherosclerosisR01HL142673 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ALEVRIADOU, BARBARA RITA, MUNISWAMY, MADESH · 2018 to 2021
$2.0M
NHLBI NIH HHS R01 HL142673NHLBI NIH HHS R01HL142673NINDS NIH HHS R01 NS119971NINDS NIH HHS R01NS119971
6 · The paper itself

Abstract

purposeOrbital shakers are used in endothelial (EC) mechanobiology to simulate hemodynamic environments, yet guidelines for selecting physiologically relevant parameters are lacking.

methodsUsing computational fluid dynamics (CFD) simulations, we investigated the effects of different orbital radii (A, at either 5 or 10 mm), angular velocities (RPM), and initial fluid heights (h

resultsWe identified operational bounds that generate undisturbed flow (UF) at the periphery and disturbed flow (DF) at the center, with WSS levels analogous to those in human arteries (peripheral: 10-14 dynes/cm

conclusionsThese insights inform orbital shaker settings that balance biological relevance with experimental practicality for EC mechanobiology studies.

Indexed as

Cellular biomechanicsComputational fluid dynamicsDisturbed vs undisturbed flowEndothelial monolayerWall shear stress

Identifiers

PMID42560592
PMCPMC13649344

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.