Evidence map›Paper›PMID 42560575›Full record

ArticleJournal of bioenergetics and biomembranes2026

Aloe vera extract disrupts mitochondrial bioenergetics and suppresses HeLa cervical cancer cell proliferation: Transcriptomic and metabolic insights into cisplatin co-treatment.

Tuğba Kul Köprülü, Burçin Erkal Çam

Abstract read
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In one paragraph

Article in Journal of bioenergetics and biomembranes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tuğba Kul KöprülüExperimental Medicine Application and Research Center, University of Health Sciences, İstanbul, 34662, Türkiye. tugbakul.koprulu@sbu.edu.tr.ORCID http://orcid.org/0000-0001-9451-5715
Burçin Erkal ÇamDepartment of Molecular Biology and Genetics, Faculty of Arts and Sciences, Yıldız Technical University, Esenler, İstanbul, Türkiye.ORCID http://orcid.org/0000-0002-0275-5613

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer remains a leading cause of cancer related mortality in women worldwide. Cisplatin (CP) is a cornerstone chemotherapeutic agent; however, its clinical utility is constrained by dose-limiting toxicity and the emergence of drug resistance, necessitating novel combinatorial strategies. This study investigated the therapeutic potential of combining CP with Aloe vera extract (AVE) against HeLa cervical cancer cells and the normal human skin fibroblast cell line CCD-1072Sk. Cytotoxicity assays performed using the xCELLigence Real-Time Cell Analysis (RTCA) system determined IC

Indexed as

AloeCisplatinEnergy MetabolismMitochondriaPlant ExtractsTranscriptomeUterine Cervical NeoplasmsCell ProliferationFemaleHeLa CellsHumansCisplatinPlant ExtractsAloe veraCervical cancerCisplatinMitochondrial bioenergeticsOxidative phosphorylationRTCATranscriptomics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.