Evidence map›Paper›PMID 42560534›Full record

ArticleSurgery today2026

Preoperative prognostic nutritional index predicts overall survival in surgically resected small cell lung cancer: A single-institution experience.

Haruaki Hino, Shinji Yuhara, Junichi Takada, Kimihiko Kobayashi, Naohiro Ijiri, Cong Yue, Keita Nakao, Gouji Toyokawa, Mitsuaki Kawashima, Chihiro Konoeda and 1 more

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Haruaki HinoDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo Bunkyo, Tokyo, 113-8655, Japan. haruakihino@gmail.com.ORCID http://orcid.org/0000-0002-6048-6319
Shinji YuharaDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo Bunkyo, Tokyo, 113-8655, Japan.
Junichi TakadaDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo Bunkyo, Tokyo, 113-8655, Japan.
Kimihiko KobayashiDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo Bunkyo, Tokyo, 113-8655, Japan.
Naohiro IjiriDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo Bunkyo, Tokyo, 113-8655, Japan.
Cong YueDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo Bunkyo, Tokyo, 113-8655, Japan.
Keita NakaoDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo Bunkyo, Tokyo, 113-8655, Japan.
Gouji ToyokawaDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo Bunkyo, Tokyo, 113-8655, Japan.
Mitsuaki KawashimaDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo Bunkyo, Tokyo, 113-8655, Japan.
Chihiro KonoedaDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo Bunkyo, Tokyo, 113-8655, Japan.
Masaaki SatoDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo Bunkyo, Tokyo, 113-8655, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSurgical lung resection, followed by chemotherapy and radiation therapy, is recommended for patients with early stage small cell lung cancer (SCLC). Combined SCLC, defined by the presence of non-SCLC, is associated with poorer survival than pure SCLC; however, reliable prognostic markers in surgically treated SCLC remain unclear. We aimed to investigate the prognostic factors for all SCLC subtypes undergoing surgery.

methodsWe retrospectively evaluated patients with SCLC who underwent lung resection at our institute between 2000 and 2022. The clinical characteristics and surgical outcomes were analyzed.

resultsAmong the 2,309 cases, 23 pure SCLC (1.00%) and 26 combined SCLC (1.12%) were identified. The patient characteristics were comparable between the groups. The 5-year overall survival rates were 46.0% for pure SCLC and 36.5% for combined SCLC, respectively (P = 0.89), while the recurrence-free survival rates were 27.7% and 30.0%, respectively (P = 0.76). A Multivariate Cox regression analysis revealed that the prognostic nutritional index (PNI) was an independent prognostic factor. Although a literature-based PNI cutoff of 45.0 was not significantly associated with survival differences (P = 0.162), our exploratory cohort-specific cutoff of 47.0 demonstrated a significant survival difference (P = 0.008), with a higher PNI associated with a better survival.

conclusionsThe preoperative nutritional status may be a useful predictive marker of postoperative survival in patients with SCLC undergoing curative surgery.

Indexed as

Combined small cell lung cancerLung cancer surgeryPrognostic factorPrognostic nutritional indexPure small cell lung cancer

Identifiers

PMID42560534

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