Evidence map›Paper›PMID 42560494›Full record

ReviewMedizinische Klinik, Intensivmedizin und Notfallmedizin2026

[Sepsis 2026: diagnosis and treatment].

Matthias Kochanek, Jan-Hendrik Naendrup

Abstract readReviewEnglish Abstract
PubMed Publisher
In one paragraph

Review in Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Matthias KochanekKlinik I für Innere Medizin und Centrum für Integrierte Onkologie, Internistische Intensivstation, Klinikum der Universität zu Köln, Kerpener Straße 62, 50937, Köln, Deutschland. matthias.kochanek@uk-koeln.de.ORCID http://orcid.org/0000-0002-4766-4651
Jan-Hendrik NaendrupKlinik I für Innere Medizin und Centrum für Integrierte Onkologie, Internistische Intensivstation, Klinikum der Universität zu Köln, Kerpener Straße 62, 50937, Köln, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis and septic shock require a standardized, time-critical approach: screening of acutely ill high-risk patients, prompt assessment of infection and sepsis-associated organ dysfunction, rapid initiation of appropriate intravenous antimicrobials, and early hemodynamic stabilization. Key elements include obtaining blood cultures before antimicrobials, balanced crystalloids as first-line fluids, norepinephrine as the main vasopressor, and-if vasopressor requirements persist-adjunctive strategies such as vasopressin or hydrocortisone ± fludrocortisone depending on the clinical scenario. Prevention (infection prevention, antibiotic stewardship (ABS)/antimicrobial stewardship (AMS) programs) and structured follow-up aim to reduce long-term sequelae after sepsis.

Indexed as

Critical CareSepsisAnti-Bacterial AgentsAntimicrobial StewardshipFluid TherapyHumansMultiple Organ FailureShock, SepticVasoconstrictor AgentsAnti-Bacterial AgentsVasoconstrictor AgentsAnti-infective agentsBlood cultureOrgan dysfunction scoresShock, septicVasoconstrictor agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.