Observational studyWorld journal of surgery2026
Associations Between Time-To-Surgery and Postoperative Length of Stay and Complications in Patients With Acute Appendicitis.
Observational study in World journal of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Associations Between Time-To-Surgery and Postoperative Length of Stay and Complications in Patients With Acute Appendicitis.World journal of surgery · 2026Observational
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcute appendicitis is a common surgical emergency. The optimal time-to-surgery interval remains debated, as studies reported increased complication risk beyond 12 or 24 hours respectively. We hypothesized that time-to-surgery of up to 24 hours after admission was not associated with increased postoperative length of stay (LOS) or complications.
methodsThis retrospective observational cohort study included adults and adolescents (≥ 15 years) undergoing laparoscopic appendectomy from January 2017-July 2025 in the Capital and the Zealand Regions of Denmark. Data were extracted from the Electronic Health Record system. The primary exposure was time-to-surgery intervals. Primary outcome was postoperative LOS. Secondary outcomes were 30-day postoperative complications. Subgroup analyses were performed for uncomplicated/complicated appendicitis. All outcomes were evaluated by multivariable regression models adjusted for predefined confounders.
resultsOf 25,417 laparoscopic appendectomies, 19,089 met eligibility criteria. Compared with time-to-surgery < 8 hours, postoperative LOS was reduced when time-to-surgery was 8-16 hours (mean difference -2.29 hours, 95% CI: -3.85 to -0.73) and 16-24 hours (-3.92 hours, 95% CI: -6.05 to -1.78). Compared with time-to-surgery < 8 hours, odds of postoperative complications were reduced for time-to-surgery up to 24 hours, whereas ≥ 36 hours was associated with increased odds (OR 1.57, 95% CI: 1.13 to 2.18). In complicated appendicitis, time-to-surgery 24-36 hours was associated with decreased postoperative LOS (-13.0 hours, 95% CI: -22 to -3.6).
conclusionTime-to-surgery of up to 24 hours was not associated with increased postoperative LOS or complications. In contrast, we observed a protective association driven by complicated appendicitis, potentially reflecting effective clinical triage.
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