Evidence map›Paper›PMID 42559947›Full record

ArticleeLife2026

LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics.

Giulia Tombesi, Shiva Kompella, Giulia Favetta, Chuyu Chen, Marta Ornaghi, Yibo Zhao, Ester Morosin, Martina Sevegnani, Adriano Lama, Antonella Marte and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Giulia TombesiDepartment of Biology, University of Padova, Padova, Italy.ORCID https://orcid.org/0000-0003-0683-8050
Shiva KompellaUK Dementia Research Institute, Cardiff University, Hadyn Ellis Building, Cardiff, United Kingdom.
Giulia FavettaDepartment of Biology, University of Padova, Padova, Italy.
Chuyu ChenNorthwestern University, Chicago, United States.ORCID https://orcid.org/0000-0001-5666-5173
Marta OrnaghiInstitute for Biochemistry, Charité Universitatsmedizin Berlin, Berlin, Germany.ORCID https://orcid.org/0009-0003-4376-4369
Yibo ZhaoSchool of Pharmacy, University College London, London, United Kingdom.
Ester MorosinDepartment of Biology, University of Padova, Padova, Italy.
Martina SevegnaniCIBIO, University of Trento, Trento, Italy.
Adriano LamaCIBIO, University of Trento, Trento, Italy.
Antonella MarteDepartment of Experimental Medicine, University of Genova, Genova, Italy.ORCID https://orcid.org/0000-0001-9842-2663
Ilaria BattistiDepartment of Biomedical Sciences, University of Padova, Padova, Italy.ORCID https://orcid.org/0009-0000-5561-6804
Lucia IannottaDepartment of Biology, University of Padova, Padova, Italy.
Nicoletta PlotegherDepartment of Biology, University of Padova, Padova, Italy.
Laura CivieroDepartment of Biology, University of Padova, Padova, Italy.
Franco OnofriDepartment of Experimental Medicine, University of Genova, Genova, Italy.ORCID https://orcid.org/0000-0001-5595-0036
Britta J EickholtInstitute for Biochemistry, Charité Universitatsmedizin Berlin, Berlin, Germany.
Giovanni PiccoliCIBIO, University of Trento, Trento, Italy.
Giorgio ArrigoniDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Dayne Beccano-KellyUK Dementia Research Institute, Cardiff University, Hadyn Ellis Building, Cardiff, United Kingdom.ORCID https://orcid.org/0000-0003-3592-8354
Claudia ManzoniSchool of Pharmacy, University College London, London, United Kingdom.
Loukia ParisiadouNorthwestern University, Chicago, United States.ORCID https://orcid.org/0000-0002-2569-4200
Elisa GreggioDepartment of Biology, University of Padova, Padova, Italy.ORCID https://orcid.org/0000-0002-8172-3598

Funding

LRRK2-mediated molecular and synaptic events in the striatumR01NS097901 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PARISIADOU, LOUKIA · 2016 to 2020
$2.0M
The Role of Striatal Astrocytic Dopamine D2 Receptor Signaling in the Pathogenesis of LRRK2-Mediated Parkinson's DiseaseR21AG089563 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PARISIADOU, LOUKIA · 2024 to 2025
$419k
Italian Ministry of Research European Union - NextGenerationEU (NRRP, Mission 4, Component 2, Investment 1.1 - PRIN, Project 20222LRHCW, CUP C53D23005560006)NIA NIH HHS R21 AG089563NIH HHS 1R21AG089563-01A1NIH HHS R01NS097901NINDS NIH HHS R01 NS097901UK Research Institute Future Leader Fellowship MR/T041129/1Università degli Studi di Padova STARS Grants, LRRKing-Role of the Parkinson's disease kinase LRRK2 in shaping neurites and synapses
6 · The paper itself

Abstract

Parkinson's disease (PD) is a multisystemic disorder that manifests through motor and non-motor symptoms. Motor dysfunction results from the degeneration of dopamine-producing neurons in the substantia nigra pars compacta. Increasing evidence suggests that synapse dysfunction precedes neuronal loss by years. Still, early synaptic alterations in PD remain poorly understood. Here, we integrate literature meta-analysis and multi-omics with biochemical, imaging, and electrophysiological measurements in

Indexed as

Actin CytoskeletonLeucine-Rich Repeat Serine-Threonine Protein Kinase-2SynapsesAnimalsBrain-Derived Neurotrophic FactorHumansMiceMice, KnockoutNeuronsParkinson DiseaseBrain-Derived Neurotrophic FactorLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanLrrk2 protein, mouseactin cytoskeletonBDNFdrebrinhumanLRRK2mouseneuroscienceParkinson's diseasesynapse

Identifiers

PMID42559947
PMCPMC13446905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.