Evidence map›Paper›PMID 42559936›Full record

ArticleeLife2026

Brainstem neurons coordinate the bladder and urethral sphincter for urination.

Xing Li, Xianping Li, Jun Li, Han Qin, Shanshan Liang, Jun Li, Tingliang Jian, Xia Wang, Lingxuan Yin, Chunhui Yuan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. From bladder to brain: How you know when it's time to go.Current opinion in neurobiology · 2025
    Review
  3. A Spinal Circuit for Modular Gating of Organ Somatosensation.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xing LiAdvanced Institute for Brain and Intelligence, School of Physical Science and Technology, Guangxi University, Nanning, China.
Xianping LiBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Jun LiAdvanced Institute for Brain and Intelligence, School of Physical Science and Technology, Guangxi University, Nanning, China.
Han QinLFC Laboratory and Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing, China.ORCID https://orcid.org/0000-0002-9421-5875
Shanshan LiangBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Jun LiBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Tingliang JianBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Xia WangCenter for Neurointelligence, School of Medicine, Chongqing University, Chongqing, China.ORCID https://orcid.org/0000-0002-0376-479X
Lingxuan YinAdvanced Institute for Brain and Intelligence, School of Physical Science and Technology, Guangxi University, Nanning, China.
Chunhui YuanDepartment of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai, China.
Xiang LiaoCenter for Neurointelligence, School of Medicine, Chongqing University, Chongqing, China.
Hongbo JiaAdvanced Institute for Brain and Intelligence, School of Physical Science and Technology, Guangxi University, Nanning, China.ORCID https://orcid.org/0000-0003-1585-2161
Xiaowei ChenBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.ORCID https://orcid.org/0000-0003-0906-6666
Jiwei YaoDepartment of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0009-0003-5063-6584

Funding

Guangxi Talent Program Highland of Innovation TalentsJiangsu Provincial Big Science Facility Initiative BM2022010National Key Research and Development Program of China 2021YFA0805000National Natural Science Foundation of China 31925018National Natural Science Foundation of China 32127801Suzhou Science and Technology Plan Project SZS2022008
6 · The paper itself

Abstract

Urination, a vital and conserved process of emptying urine from the urinary bladder in mammals, requires precise coordination between the bladder and external urethral sphincter (EUS) that is tightly controlled by a complex neural network. However, the specific subpopulation of neurons that accounts for such coordination remains unidentified, limiting the development of target-specific therapies for certain urination disorders, for example, detrusor-sphincter dyssynergia. Here, we find that cells expressing estrogen receptor 1 (ESR1

Indexed as

Brain StemNeuronsUrethraUrinary BladderUrinationAnimalsEstrogen Receptor alphaFemaleMiceEstrogen Receptor alphabladderestrogen receptor 1 (ESR1)-positive neuronsmouseneurosciencepontine micturition centersphincterspinal cordurination

Identifiers

PMID42559936
PMCPMC13446904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.