Evidence map›Paper›PMID 42559809›Full record

ArticleeLife2026

Endometrial cells with high ALDH activity contribute to uterine development and regeneration.

Suni Tang, Anna Catherine Unser, Peixin Jiang, Sydney E Parks, Genesis J Herrera, Ting Geng, Linda Alpuing Radilla, Brooke A Thigpen, Xiaoming Guan, Diana Monsivais

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Suni TangDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, United States.
Anna Catherine UnserDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, United States.ORCID https://orcid.org/0009-0001-4678-1469
Peixin JiangDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, United States.
Sydney E ParksDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, United States.
Genesis J HerreraDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, United States.
Ting GengDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, United States.
Linda Alpuing RadillaDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, United States.
Brooke A ThigpenDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, United States.
Xiaoming GuanDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, United States.
Diana MonsivaisDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, United States.ORCID https://orcid.org/0000-0001-5660-6392

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
Discovery and development of potent inhibitors of Jun N-terminal kinase for non-hormonal treatment of endometriosis and associated painR01HD099341 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MONSIVAIS, DIANA · 2021 to 2025
$2.8M
Targeting the endometrial stem cell niche inendometriosisR01HD105800 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Diana Monsivais · 2022 to 2026
$2.5M
ACQUISITION OF THE YOKOGAWA CV8000 HIGH THROUGHPUT SPINNING DISK MICROSCOPE AND ROBOTICSS10OD030414 · OD · BAYLOR COLLEGE OF MEDICINE · PI MANCINI, MICHAEL A. · 2022 to 2022
$1.4M
CyTOF XT with Hyperion XTi platformS10OD036336 · OD · BAYLOR COLLEGE OF MEDICINE · PI BEETON, CHRISTINE · 2024 to 2024
$829k
Burroughs Wellcome Fund NGP10125Eunice Kennedy Shriver National Institute of Child Health and Human Development HD099341Eunice Kennedy Shriver National Institute of Child Health and Human Development HD105800Lalor Foundation FellowshipNCI NIH HHS P30 CA125123NICHD NIH HHS R01 HD099341NICHD NIH HHS R01 HD105800NIDDK NIH HHS P30 DK056338NIH HHS S10 OD030414NIH HHS S10 OD036336
6 · The paper itself

Abstract

Adult stem cells are thought to drive the regenerative potential of the endometrium and contribute to the pathogenesis of endometriosis; however, their identity and defining features remain to be characterized. Here, we used in vivo and in vitro approaches to demonstrate that cells with high aldehyde dehydrogenase 1 activity (ALDH

Indexed as

Aldehyde Dehydrogenase 1 FamilyEndometriumRegenerationRetinal DehydrogenaseUterusAnimalsEpithelial CellsFemaleHumansMiceAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, mouseRetinal DehydrogenaseendometriosisendometriumhumanLineage tracingmouseorganoidprogenitorsregenerative medicinestem cells

Identifiers

PMID42559809
PMCPMC13446906

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.