Evidence map›Paper›PMID 42559795›Full record

ArticleEuropean journal of neurology2026

Italian Delphi Consensus on Maternity Care in Multiple Sclerosis: Toward an Interdisciplinary Model of Care.

Emilio Portaccio, Paola Cavalla, Lucia Moiola, Francesco Patti, Luca Marozio, Paolo Palma, Martina Campobasso, Federica Balzani, Alessia Villani, Valentina Sara Barbiero and 4 more

Abstract readConsensus Statement
In one paragraph

Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Emilio PortaccioDepartment of Neurofarba, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-9662-1762
Paola CavallaDepartment of Neurosciences Rita Levi Montalcini, University of Turin, Turin, Italy.
Lucia MoiolaMultiple Sclerosis Center and Neurology Department, IRCCS Ospedale San Raffaele, Milan, Italy.
Francesco PattiDepartment of Medical and Surgical and Advanced Technologies, G F Ingrassia, University of Catania-UOS Sclerosi Multipla, AOU Policlinico "G Rodolico-San Marco", Catania, University of Catania, Catania, Italy.
Luca MarozioUniversity of Turin School of Medicine, Obstetrics and Gynecology, Turin, Italy.
Paolo PalmaBambino Gesù Children's Hospital IRCCS, Rome, Unit of Clinical Immunology and Vaccinology, Rome, Italy.
Martina CampobassoFondazione PTV, Policlinico Tor Vergata, Rome, Italy.
Federica BalzaniAssociazione Italiana Sclerosi Multipla, International Stakeholders and Corporate Pharma Relations, Genoa, Italy.
Alessia VillaniAssociazione Italiana Sclerosi Multipla, Patient Advocacy & Public Affairs, Genoa, Italy.
Valentina Sara BarbieroRoche SpA, Monza, Italy.
Daniela FacchinelloRoche SpA, Monza, Italy.
Raffaella RobelloRoche SpA, Monza, Italy.
Girolama Alessandra MarfiaDepartment of Systems Medicine Multiple Sclerosis Clinical and Research Unit, Tor Vergata University, Rome, Italy.
Maternity Care Delphi Expert Panel

Funding

Roche Italia
6 · The paper itself

Abstract

backgroundReproductive health is a critical component of care for women with multiple sclerosis (MS), yet standardized interdisciplinary approaches remain limited.

objectivesThis Delphi consensus aimed to develop an interdisciplinary, evidence-informed care model tailored to the Italian healthcare system.

resultsA two-round Delphi process was conducted in Italy (June-July 2025), involving MS experts (Round 1: 107, Round 2: 95), including neurologists, gynecologists, pediatricians, nurses, and patient representatives. Participants evaluated key aspects of the reproductive care pathway, from preconception counseling to postpartum follow-up, to identify priorities and areas of agreement across disciplines. Strong consensus was achieved on the importance of early counseling, coordinated interdisciplinary management, and individualized treatment planning across the reproductive continuum. The central role of nurses in patient education was also emphasized. Divergence emerged regarding the continuation of specific therapies during pregnancy and the role of neonatal immunological monitoring following exposure to depleting agents, reflecting areas of ongoing uncertainty and limited evidence.

conclusionsThis consensus proposes the first interdisciplinary framework for reproductive care in MS within the Italian context. It emphasizes patient-centered decision-making, collaboration across specialties, and the integration of reproductive health into routine MS management. By identifying both shared priorities and unresolved challenges, it provides a foundation for more harmonized, evidence-informed clinical practice and future research.

Indexed as

Multiple SclerosisPatient Care TeamPregnancy ComplicationsDelphi TechniqueFemaleHumansItalyPregnancyDelphi consensusinterdisciplinary caremultiple sclerosispregnancyreproductive health

Identifiers

PMID42559795
PMCPMC13445565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.