Evidence map›Paper›PMID 42559775›Full record

ArticleJACC. Asia2026

Impact of Device Position and Aortic Valve Prolapse on Outcomes After Transcatheter VSD Closure.

Tzu-Huan Lin, Jou-Kou Wang, Ming-Tai Lin, Hsin-Ming Liu, Jui-Yu Hsu, Ya-Mei Chang, Yi-Fang Wang, Shuenn-Nan Chiu, Chun-Wei Lu, Mei-Hwan Wu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tzu-Huan LinDepartment of Cardiology, National Taiwan University Children's Hospital, Taipei, Taiwan.
Jou-Kou WangDepartment of Cardiology, National Taiwan University Children's Hospital, Taipei, Taiwan.
Ming-Tai LinDepartment of Cardiology, National Taiwan University Children's Hospital, Taipei, Taiwan; Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Hsin-Ming LiuDepartment of Cardiology, National Taiwan University Children's Hospital, Taipei, Taiwan; Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Jui-Yu HsuDianthus MFM Clinic, Taipei, Taiwan.
Ya-Mei ChangDianthus MFM Clinic, Taipei, Taiwan.
Yi-Fang WangDepartment of Pediatrics, Taipei City Hospital Renai Branch, Taipei, Taiwan.
Shuenn-Nan ChiuDepartment of Cardiology, National Taiwan University Children's Hospital, Taipei, Taiwan; Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chun-Wei LuDepartment of Cardiology, National Taiwan University Children's Hospital, Taipei, Taiwan; Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Mei-Hwan WuDepartment of Cardiology, National Taiwan University Children's Hospital, Taipei, Taiwan; Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Wei-Chieh TsengDepartment of Cardiology, National Taiwan University Children's Hospital, Taipei, Taiwan; Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Ming-Chun YangDepartment of Pediatrics, E-DA Hospital, Kaohsiung, Taiwan; College of Medicine, I-SHOU University, Kaohsiung, Taiwan.
Chun-An ChenDepartment of Cardiology, National Taiwan University Children's Hospital, Taipei, Taiwan; Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: chenca@ntu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscatheter closure of ventricular septal defect (VSD) is a promising alternative to surgery; however, outcomes in patients with coexisting aortic valve prolapse (AVP) remain limited.

objectivesThe authors aimed to evaluate outcomes and risk factors after VSD closure using the KONAR-MF Occluder (MFO) in a large Asian cohort with a high prevalence of AVP.

methodsBetween 2021 and 2024, consecutive patients undergoing transcatheter VSD closure at our institution using only the MFO were enrolled. Right coronary cusp (RCC) prolapse was quantified using the RCC prolapse index on transesophageal echocardiography. Device position relative to the aortic cusp was classified as nontouching, clamping, or holding. Risk factors for procedural failure and progression of aortic regurgitation (AR) were analyzed.

resultsAmong 109 cases (13.8%, 15 of 109 doubly committed [Dc] type), 61.5% (67 of 109) had AVP. The procedural success rate was 94.5% (103 of 109; 95% CI: 88.4%-98.0%). Younger age, Dc VSD, aortic rim deficiency, and larger defect size were univariate correlates of failure, whereas RCC prolapse index was the only independent predictor in multivariate analysis (OR: 2.48; 95% CI: 1.06-5.83 per 10% increase; P = 0.037). During a median (IQR) follow-up of 14.3 (8.4-22.8) months, AR progression occurred in 7 (6.8%) patients. Device clamping of the aortic cusp was associated with AR progression (OR: 6.67; 95% CI: 1.10-58.1; P = 0.048).

conclusionsVSD closure using the MFO is safe and effective, including in patients with outlet-type VSD and AVP. Significant RCC prolapse predicts procedural failure, and clamping of the aortic cusp may compromise long-term valve function.

Indexed as

aortic regurgitationKONAR-MF Occluderright coronary cusp prolapse indexventricular septal defect

Identifiers

PMID42559775
PMCPMC13654372

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.