Evidence map›Paper›PMID 42559715›Full record

ArticleeLife2026

Heterotypic interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epithelia.

Amrapali Datta, Phanindra Dewan, Aswin Anto Puthoor, Tanya Chhabra, Tanishq Tejaswi, Sindhu Muthukrishnan, Akshar Rao, Sumantra Sarkar, Medhavi Vishwakarma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amrapali DattaDepartment of Bioengineering, Indian Institute of Science, Bengaluru, India.ORCID https://orcid.org/0009-0007-5400-2211
Phanindra DewanDepartment of Physics, Indian Institute of Science, Bengaluru, India.ORCID https://orcid.org/0009-0007-2382-7069
Aswin Anto PuthoorDepartment of Bioengineering, Indian Institute of Science, Bengaluru, India.
Tanya ChhabraDepartment of Physics, Syracuse University, Syracuse, United States.
Tanishq TejaswiDepartment of Bioengineering, Indian Institute of Science, Bengaluru, India.
Sindhu MuthukrishnanDepartment of Bioengineering, Indian Institute of Science, Bengaluru, India.ORCID https://orcid.org/0009-0005-2962-8082
Akshar RaoDepartment of Bioengineering, Indian Institute of Science, Bengaluru, India.
Sumantra SarkarDepartment of Physics, Indian Institute of Science, Bengaluru, India.
Medhavi VishwakarmaDepartment of Bioengineering, Indian Institute of Science, Bengaluru, India.ORCID https://orcid.org/0000-0002-8582-5217

Funding

Anusandhan National Research Foundation SERB SRG/2022/000534Anusandhan National Research Foundation SRG/2022/000163Indo-German Science & Technology Centre WISER awardMax Planck Society Max Planck partner group
6 · The paper itself

Abstract

Why does the same oncogenic mutation drive tumor formation in some tissues but not in others? While cancer driver mutations are well documented, their tissue-specific effects remain largely attributed to genetic factors, leaving the biophysical aspects underexplored. Here, we demonstrate that mechanical interactions between newly transformed and wild-type cells are critical in determining survival and growth of HRas

Indexed as

CarcinogenesisEpithelial CellsBronchiCell MovementEpitheliumFemaleHumansMammary Glands, HumanMutationProto-Oncogene Proteins p21(ras)HRAS protein, humanProto-Oncogene Proteins p21(ras)breast epithelial cellscancer biologylung epithelial cellsmammalian cells

Identifiers

PMID42559715
PMCPMC13446903

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.