Evidence map›Paper›PMID 42559704›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

AARS1-Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8

Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ying ZhuCenter For Global Health, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Suzhou Institute for Advanced Study of Public Health, Gusu School, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Jiaheng LinCenter For Global Health, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Suzhou Institute for Advanced Study of Public Health, Gusu School, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Yifan LiDepartment of Respiratory and Critical Care Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, People's Republic of China.
Qiaoqiao ZhouDepartment of Respiratory and Critical Care Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, People's Republic of China.
Min YuDepartment of Respiratory and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou, Jiangsu, People's Republic of China.
Cheng ChengCenter For Global Health, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Suzhou Institute for Advanced Study of Public Health, Gusu School, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Kang ChangDepartment of Respiratory and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou, Jiangsu, People's Republic of China.
Dang LinDepartment of Respiratory and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou, Jiangsu, People's Republic of China.
Tao BianDepartment of Respiratory and Critical Care Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, People's Republic of China.
Yan WuDepartment of Respiratory and Critical Care Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, People's Republic of China.ORCID https://orcid.org/0009-0006-2767-9297
Lu LuAnimal Core Facility, Jiangsu Animal Experimental Center of Medical & Pharmaceutical Research, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Haibo XiaCenter For Global Health, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Suzhou Institute for Advanced Study of Public Health, Gusu School, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.ORCID https://orcid.org/0000-0003-1097-6894
Qizhan LiuCenter For Global Health, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Suzhou Institute for Advanced Study of Public Health, Gusu School, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.ORCID https://orcid.org/0000-0001-6107-9232

Funding

Basic Research Program of Jiangsu BK20240523Basic Research Program of Jiangsu BK20250307China Postdoctoral Science Foundation 2025M770751Jiangsu Funding program for Excellent Postdoctoral Talent 2025ZB419Jiangsu Postgraduate Scientific Research Innovation Plan SJCX24_0805Medical Key Strategic Project of Wuxi Health Commission 2025TH-GD-WY-2025National Natural Science Foundation of China 82504445National Natural Science Foundation of China 82574132
6 · The paper itself

Abstract

Emphysema is the primary pathological feature of chronic obstructive pulmonary disease (COPD). The accumulation of CD8

Indexed as

AARS1CD8+T cell activationcytotoxicityemphysemalactylationsmoking

Identifiers

PMID42559704
PMCPMC13445330

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.