ArticlePlastic and reconstructive surgery. Global open2026
Current Use of Hyperbaric Oxygen Therapy in Plastic Surgery: A Systematic Review.
Article in Plastic and reconstructive surgery. Global open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hyperbaric oxygen therapy (HBOT) involves delivering 100% oxygen at pressures greater than 1 atmosphere and is used in several specialties. In plastic surgery, HBOT has been applied to ischemic wounds, compromised flaps, and tissue injury. Despite its growing use, comprehensive evaluations of its indications, complications, and outcomes remain limited. Methods: A systematic review was performed in February 2025 using PubMed, Embase, and Cochrane. The Preferred Reporting for Items for Systematic Reviews and Meta-Analyses guidelines were followed. Abstracts and full texts were reviewed independently by 2 reviewers, with a third reviewer resolving disagreements. Included studies evaluated HBOT in plastic surgery indications, including wounds, grafts, flaps, infections, and extremity limb salvage. Results: The search yielded 355 studies, of which 30 underwent full-text review and 18 met inclusion criteria. These studies included 1281 patients, with 786 treated with HBOT and 495 without. Study designs included cohort studies (16.6%), case-control studies (5.6%), randomized controlled trials (11.1%), and case series (66.6%). Meta-analysis demonstrated a 52% reduction in complication rates with HBOT (odds ratio 0.48; 95% confidence interval: 0.09, 2.66; Conclusions: HBOT shows benefit as an adjunct in plastic surgery, particularly for chronic wounds, limb preservation, and flap or graft salvage. Further standardized studies are needed to define optimal treatment protocols and patient selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.