ArticleCytoJournal2026
Long non-coding RNA LOC101926915-encoded micropeptide carboplatin-induced upregulation factor confers carboplatin resistance in ovarian cancer.
Article in CytoJournal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: While carboplatin remains a cornerstone chemotherapeutic agent for ovarian carcinoma, the emergence of resistance constitutes a major contributor to therapeutic failure and compromised clinical outcomes. This study elucidates molecular mechanisms driving carboplatin resistance and identifies novel therapeutic targets for carboplatin-refractory malignancies through characterization of a long non-coding RNA (lncRNA)-encoded micropeptide. Material and Methods: Ribosome profiling analysis delineated translational alterations induced by carboplatin in ovarian cancer models. Mechanistic validation was achieved through the integration of gain- and loss-of-function methodologies, nuclear localization assays, and quantitative assessment of deoxyribonucleic acid (DNA) damage through enumeration of gamma-H2AX (phosphorylated histone H2AX at serine 139) foci, supplemented by alkaline comet analysis. The therapeutic significance was corroborated using subcutaneous xenograft models derived from patient-derived ovarian cancer cells. Results: The micropeptide carboplatin-induced upregulation factor (CARUF), derived from lncRNA LOC101926915, was markedly upregulated in response to carboplatin treatment, with ribosome profiling showing significant enrichment of ribosome-associated LOC101926915 transcripts (adjusted Conclusion: Our findings identify CARUF as a critical mediator of aberrant DNA damage response signaling in carboplatin-resistant ovarian cancer, indicating its potential as a druggable target for overcoming carboplatin resistance.
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