ArticleNeuro-oncology pediatrics2026
The DIPG/DMG National Tumor Board: The power of advocacy.
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Article in Neuro-oncology pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
17 authors.
Rebecca RonsleyBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).ORCID 0000-0003-3961-3042
Greta PengBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).
Eileen GutierrezBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).
Patricia BaxterBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).
Jason FangusaroBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).ORCID 0000-0003-3099-5259
Adam L GreenBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).
Lindsay B KilburnBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).
Carl KoschmannBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).
Jasia MahdiBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).
Michelle MonjeBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).ORCID 0000-0002-3547-237X
Ashley S Plant-FoxBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).
Nicholas A VitanzaBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).
Sebastian M WaszakBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).ORCID 0000-0003-3042-9521
Cheng-Chia Fred WuBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).
Matthew J BarkovichBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).
David MirskyBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).ORCID 0000-0003-2162-515X
Sabine MuellerBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, United States (R.R., N.A.V.); Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, United States (R.R., N.A.V.); Seattle Children's Therapeutics, Seattle, WA, United States (R.R., N.A.V.); Departments of Pediatrics and Neurology, University of California, San Francisco, San Francisco, CA, United States (G.P., E.G., S.M.W., M.J.B., S.M.); Texas Children's Hospital, Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, United States (P.B., J.M.); Children's Healthcare of Atlanta and the Aflac Cancer Center, Emory University School of Medicine, Atlanta, GA, United States (J.F.); Children's Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO, United States (A.L.G.); Center for Cancer and Blood Disorders and The Brain Tumor Institute, Children's National Hospital, Wasthington, DC, United States (L.B.K.); Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States (C.K.); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States (M.M.); Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States (A.S.P.-F.); Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospital, Oslo, Norway (S.M.W.); Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (S.M.W.); Radiation Oncology, Frailin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States (C.-C.F.W.); Department of Radiation Oncology, Children's National Hospital Brain Tumor Institute, Washington, DC, United States (C.-C.F.W.); Radiation Oncology, Inova Schar Cancer Institute, Fairfax, VA, United States (C.-C.F.W.); Children's Hospital of Colorado, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States (D.M.); Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States (S.M.).ORCID 0000-0002-3452-5150
Funding
B7-H3 CAR T cells following initial radiation for children and young adults with diffuse intrinsic pontine gliomaR37CA289981 · NCI · SEATTLE CHILDREN'S HOSPITAL · PI Nicholas A Vitanza · 2025 to 2026
$930kNCI NIH HHS R37 CA289981
Abstract
Background: Diffuse intrinsic pontine gliomas (DIPG) and diffuse midline gliomas (DMG) are fatal brain tumors and clinical trial enrollment remains a cornerstone of treatment; however, barriers to trial identification, access and enrollment persist. The DIPG/DMG National Brain Tumor Board (DMG NTB) was created based on family foundation advocacy to address these challenges by providing centralized, multidisciplinary guidance to improve access to expertise and facilitate clinical trial awareness and enrollment. Methods: We conducted a retrospective descriptive analysis of cases presented to the DMG NTB between November 2022 and December 2024. Data were extracted from standardized intake forms, meeting records and chart reviews, including patient demographics, disease characteristics, molecular findings, referring institution type, trial recommendations, and radiologic evaluations. Geographic reach and provider participation were also analyzed. Results: A total of 349 presentations representing 279 unique patients were reviewed. Referrals came from 93 institutions across 35 states, including 48% from treating physicians, 34% via self-referral, and 18% from My DIPG Navigator. The median age was 9 years (range: 1-52), and 83% of patients had undergone tumor biopsy, with molecular profiling available in 81% of those cases. The DMG NTB provided a median of six clinical trial options. Imaging review resulted in additional findings, recommendations, or both in over half of cases. Participation grew by 89.5% over the evaluated time period. Conclusions: The DMG NTB has established a scalable, patient-centered system that enhances trial awareness, eligibility screening, care coordination, and multidisciplinary learning for patients with DIPG/DMG. This parent-driven initiative addresses longstanding gaps in access to expertise. Ongoing integration with research networks will be critical to maximizing its impact on outcomes for children and young adults.
Indexed as
advocacydiffuse intrinsic pontine gliomadiffuse midline gliomaoncologypediatric
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